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Prospectives of Antihypertensive Nano-ceuticals as Alternative Therapeutics

Taskeen Niaz1, Zeeshan Hafeez2, Muhammad Imran3

  • 1Department of Biosciences, Faculty of Sciences, COMSATS Institute of Information Technology, Park road, Islamabad. Pakistan.

Current Drug Targets
|July 13, 2016
PubMed

Insights

Novel chitosan-based antihypertensive nano-ceuticals offer improved oral bioavailability and reduced side effects compared to conventional drugs. These nano-medicines provide sustained release, enhancing therapeutic outcomes for hypertension management.

Area of Science:

  • Nanotechnology in Pharmaceutical Sciences
  • Biomaterials for Drug Delivery
  • Cardiovascular Therapeutics

Background:

  • Cardiovascular diseases (CVDs), primarily driven by hypertension, represent a leading global cause of mortality.
  • Current antihypertensive (AHT) therapies, including ACE inhibitors, ARBs, and CCBs, suffer from low oral bioavailability and significant adverse effects like angioedema and extreme hypotension.
  • These limitations necessitate the development of advanced drug delivery systems to improve therapeutic efficacy and patient safety.

Purpose of the Study:

  • To explore the potential of antihypertensive nano-medicines for controlled and targeted drug release, aiming to mitigate the side effects of conventional AHT therapies.
  • To review the advantages of nano-medicines over traditional AHT drugs and analyze recent advancements in bio-based nano/micro-carrier systems.

Main Methods:

  • Comprehensive literature review of antihypertensive drug mechanisms and current therapeutic strategies.
  • Analysis of scientific reports on bio-based nano/micro-carrier systems for AHT drug delivery.
  • In-depth evaluation of chitosan as a potential nano-carrier for AHT drugs, focusing on its properties.

Main Results:

  • Biopolymer-based nano-carrier systems offer promising avenues for safe and effective nano drug delivery.
  • Chitosan exhibits unique properties, including muco-adhesion, permeation enhancement, biocompatibility, and biodegradability, making it a suitable candidate for AHT drug delivery.
  • Nano-medicines demonstrate significant advantages over conventional AHT drugs in terms of efficacy and safety.

Conclusions:

  • Chitosan-based antihypertensive nano-ceuticals can enhance oral bioavailability and increase the plasma half-life of AHT drugs.
  • Sustained drug release in the lower gastrointestinal tract (GIT) is achievable with these novel nano-ceuticals.
  • This approach holds potential for improving hypertension management and reducing associated adverse effects.
Abstract

Keywords:
ACE-inhibitorsNano carrier systemsantihypertensive therapieschitosan nano-particlesdrug delivery.hypertension

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