Related Experiment Video
Updated: Mar 18, 2026

CRISPR Gene Editing Tool for MicroRNA Cluster Network Analysis
Published on: April 25, 2022
[Association between microRNA single nucleotide polymorphisms and the risk of hepatocellular carcinoma]
Background:
Hepatocellular carcinoma (HCC) has a high morbidity and mortality. Single nucleotide polymorphisms (SNPs) of microRNA (miRNA) may be associated with the susceptibility to develop certain malignant tumors.
Aim:
To study the association between SNPs of miRNA and hepatocellular carcinoma in peripheral blood samples.
Material And Methods:
Three SNPs in miRNA were studied in peripheral blood samples of 498 patients with HCC and 520 controls.
Results:
A significant association was observed between rs13299349 in miRNA3152 and HCC. AA genotype or A allele were significantly associated with increased risk of HCC. A allele was associated with the size and number of tumor foci. There was also a relationship between rs10061133 in miRNA449b and HCC. The G allele was significantly associated with increased risk of HCC compared with A allele.
Conclusions:
This study links rs13299349 in miRNA3152 and rs10061133 in miRNA449b with the risk of developing HCC.
Related Concept Videos
MicroRNAs
MicroRNAs
MicroRNAs
Single Nucleotide Polymorphisms-SNPs
lncRNA - Long Non-coding RNAs
Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu

