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In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions
Published on: October 21, 2022
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Implications of non-coding RNAs in viral infections
Nikhil Sharma1, Sunit K Singh2
1Laboratory of Neurovirology and Inflammation Biology, CSIR-Centre for Cellular and Molecular Biology (CCMB), Hyderabad, India.
Reviews in Medical Virology
|July 13, 2016
Summary
Non-coding RNAs (ncRNAs) regulate gene expression without producing proteins. Viruses manipulate host ncRNAs and encode their own microRNAs (miRNAs) to influence infection and pathogenesis.
Area of Science:
- Molecular Biology
- Genetics
- Virology
Background:
- Advances in RNA sequencing reveal diverse non-coding RNAs (ncRNAs) that regulate gene expression.
- ncRNAs, including microRNAs (miRNAs), play crucial roles in cellular machinery and gene regulation.
- Viral infections significantly alter host cell ncRNA profiles.
Purpose of the Study:
- To explore the intricate relationship between viral infections and non-coding RNAs.
- To understand how viruses modulate host ncRNA expression and utilize ncRNAs for pathogenesis.
- To elucidate the complex host-virus interactions mediated by ncRNAs.
Main Methods:
- RNA sequencing to identify and quantify ncRNAs.
- Analysis of miRNA expression patterns in host cells during viral infection.
- Investigating viral-encoded miRNAs and their roles.
Main Results:
- Viruses modulate the abundance and distribution of host ncRNAs.
- Viruses can encode their own miRNAs to facilitate their life cycle and pathogenesis.
- ncRNA expression patterns are significantly altered during viral infections.
Conclusions:
- Viruses employ ncRNA-based strategies for survival and replication.
- ncRNAs are key players in the complex interplay between viruses and their hosts.
- Understanding these ncRNA-virus interactions is crucial for deciphering host-pathogen dynamics.
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