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Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
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Erectile Dysfunction in Systemic Sclerosis.

Veronika K Jaeger1, Ulrich A Walker2

  • 1Department of Rheumatology, University Hospital Basel, Petersgraben 4, 4031, Basel, Switzerland.

Current Rheumatology Reports
|July 13, 2016
PubMed
Summary
This summary is machine-generated.

Erectile dysfunction (ED) affects most men with systemic sclerosis (SSc) due to microangiopathic issues. While treatments offer limited benefits, penile prosthesis implantation is a viable option when other therapies fail.

Keywords:
CausesErectile dysfunctionPrevalenceRisk factorsSystemic sclerosisTreatment

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Area of Science:

  • Rheumatology
  • Urology
  • Vascular Medicine

Background:

  • Erectile dysfunction (ED) affects 80-90% of men with systemic sclerosis (SSc), significantly impacting quality of life.
  • Unlike general ED, SSc-related ED is primarily caused by microangiopathic changes, not atherosclerosis.
  • Reduced blood flow in penile arteries results from fibrosis and myointimal proliferation in SSc patients.

Purpose of the Study:

  • To highlight the prevalence and unique etiology of ED in systemic sclerosis.
  • To review current treatment options for ED in SSc patients.
  • To discuss the role of penile prosthesis implantation for refractory ED in SSc.

Main Methods:

  • Literature review of studies on ED in systemic sclerosis.
  • Analysis of the pathophysiology of ED in SSc.
  • Evaluation of treatment efficacy for ED in SSc.

Main Results:

  • ED is highly prevalent in SSc, with microangiopathy as the primary cause.
  • On-demand PDE5 inhibitors show minimal efficacy.
  • Daily/alternate-day regimens of long-acting PDE5 inhibitors offer limited improvement.

Conclusions:

  • ED is a common and impactful complication of systemic sclerosis.
  • Current medical treatments for ED in SSc provide limited benefits.
  • Penile prosthesis implantation is a recommended option for severe, refractory ED in SSc.