Zosteriform Secondary Cutaneous Diffuse Large B-Cell Lymphoma on FDG PET/CT

Area of Science:

• Oncology
• Dermatology
• Nuclear Medicine

Background:

• Follicular lymphoma is a type of non-Hodgkin lymphoma.
• Chemotherapy is a common treatment for advanced follicular lymphoma.
• Cutaneous lymphomas can manifest in various ways, sometimes mimicking other dermatological conditions.

Observation:

• A patient previously treated for advanced follicular lymphoma presented with erythematous papules on the abdomen.
• The patient reported accompanying symptoms of numbness and local heat sensation in the affected area.
• Imaging with F-FDG PET/CT showed distinct band-like hypermetabolic lesions suggestive of dermatomal involvement.

Findings:

• The F-FDG PET/CT findings indicated neoplastic infiltration along the lower abdominal wall.
• Skin biopsy confirmed the presence of secondary cutaneous diffuse large B-cell lymphoma.
• This diagnosis highlights a rare but significant complication in patients with a history of lymphoma.

Implications:

• This case underscores the importance of considering secondary cutaneous lymphoma in patients with a history of B-cell malignancies presenting with unusual skin manifestations.
• F-FDG PET/CT can be a valuable tool in identifying and characterizing cutaneous lymphoma involvement.
• Early diagnosis and appropriate management are crucial for improving outcomes in patients with secondary cutaneous diffuse large B-cell lymphoma.