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Drugs can be classified according to their chemical composition or their intended therapeutic application. For instance, anti-infective agents that possess the ability to eliminate pathogens or suppress their growth and reproduction can be grouped based on the organisms they target or their chemical structure. Furthermore, drugs can be divided into prescription, nonprescription, or controlled substances. Prescription medications, such as antibiotics, require oversight from a licensed healthcare...
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Evaluation of Antioxidant and Anthelmintic Properties of Tithonia diversifolia Extracts Against Gastrointestinal Nematode Eggs Using In Vitro Assays
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[ANTHELMINTIC SUBSTANCES: MAIN CLASSES, PROBLEMS, TRENDS IN DEVELOPMENT AND PROSPECTS].

M Kh Dzhafarov, F Vasilevich, A S Dovgalev

    Meditsinskaia Parazitologiia I Parazitarnye Bolezni
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    This review explores current and novel anthelmintic drugs, discussing their mechanisms, resistance, and alternatives for effective deworming strategies.

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    Area of Science:

    • Veterinary Pharmacology
    • Parasitology
    • Drug Discovery

    Background:

    • Anthelmintic drugs are crucial for controlling parasitic worm infections in humans and animals.
    • A wide array of anthelmintic classes have been developed over time, each with specific mechanisms.
    • Emerging resistance necessitates continuous research into new and effective deworming agents.

    Purpose of the Study:

    • To provide a chronological overview of major anthelmintic drug classes.
    • To highlight novel anthelmintic substances and future research directions.
    • To discuss molecular mechanisms, resistance patterns, and alternative deworming approaches.

    Main Methods:

    • Literature review of anthelmintic compounds.
    • Chronological analysis of drug classes: early compounds, benzimidazoles, imidazolthiazoles, tetrahydropyrimidines, avermectins/milbemycins, and salicylanilides.
    • Focus on novel agents like emodepside, monepantel, derquantel, and tribendimidine.

    Main Results:

    • Comprehensive summary of established anthelmintic classes and their evolution.
    • Detailed examination of newer anthelmintics with potential for improved efficacy.
    • Discussion on the challenges posed by anthelmintic resistance and exploration of alternative strategies.

    Conclusions:

    • Understanding the history and mechanisms of anthelmintics is key to combating resistance.
    • Novel compounds like emodepside and monepantel represent significant advancements in deworming.
    • Continued research into drug action, resistance, and alternative methods is vital for future parasitic control.