Discovery and Structure-Activity Relationships of a Highly Selective Butyrylcholinesterase Inhibitor by
Satish N Dighe1, Girdhar Singh Deora1, Eugenio De la Mora2
1School of Pharmacy, The University of Queensland , Brisbane, Queensland 4072, Australia.
Abstract:
Structure-based virtual screening of two libraries containing 567 981 molecules was used to discover novel, selective BuChE inhibitors, which are potentially superior symptomatic treatments in late-stage Alzheimer's disease. Compound 16 was identified as a highly selective submicromolar inhibitor of BuChE (huBuChE IC50 = 0.443 μM) with high permeability in the PAMPA-BBB model. The X-ray crystal structure of huBuChE in complex with 16 revealed the atomic-level interactions and offers opportunities for further development of the series.
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