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Relationship between Hypothalamic-Pituitary-Adrenal Axis Function and Leptin Release.

Y Uehara1, H Shimizu1, K Ohtani1

  • 1a The First Department of Internal Medicine , Gunma University School of Medicine , Gunma , Japan.

Nutritional Neuroscience
|July 14, 2016
PubMed
Summary

Sympathetic activity, influenced by corticotropin-releasing hormone (CRH), affects leptin levels. Studies show CRH activation and starvation decrease leptin, impacting feeding behaviors and homeostasis.

Keywords:
AdrenalectomyCorticosteroneCorticotropin-releasing hormone (CRH)LeptinRatStarvation

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Area of Science:

  • Neuroendocrinology
  • Metabolic regulation
  • Adipose tissue biology

Background:

  • Sympathetic nervous system activation is linked to hypothalamic corticotropin-releasing hormone (CRH) release.
  • CRH may influence ob gene expression and subsequent leptin production in vivo.

Purpose of the Study:

  • To investigate the impact of modulating sympathetic activity on circulating leptin concentrations.
  • To determine the role of CRH and adrenal hormones in regulating leptin production.

Main Methods:

  • Experiments involved male Wistar rats subjected to adrenalectomy, corticosterone supplementation, intracerebro-ventricular CRH infusion, and starvation.
  • Serum leptin concentrations were measured.
  • Ob gene expression in adipose tissue was assessed using reverse transcription-polymerase chain reaction (RT-PCR).

Main Results:

  • Adrenalectomy significantly reduced serum leptin, an effect reversed by corticosterone supplementation.
  • Intracerebro-ventricular CRH infusion decreased serum leptin levels within 2 hours.
  • Starvation reduced both adipose tissue ob gene expression and serum leptin concentrations.

Conclusions:

  • Activation of the CRH-adrenocorticotropic hormone (ACTH) axis inhibits leptin production from adipose tissue.
  • Reduced leptin may contribute to maintaining homeostasis by disinhibiting hypothalamic feeding centers.