Related Experiment Video
Updated: Mar 18, 2026
A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis
Published on: May 14, 2013
Long-Term Outcome After Carotid Artery Stenting: A Population-Based Matched Cohort Study
Magnus Jonsson1, David Lindström2, Peter Gillgren2
1From the Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, and Department of Surgery, Södersjukhuset, Stockholm, Sweden (M.J., P.G., J.M.); Institute of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden (D.L.); Department of Vascular Surgery, Karolinska University Hospital, Stockholm, Sweden (D.L.); and Department of Surgical Sciences, Section of Vascular Surgery, Uppsala University, Sweden (A.W.). magnus.jonsson@sodersjukhuset.se.
Background And Purpose:
Long-term outcome after carotid artery stenting (CAS), a less invasive technique than carotid endarterectomy (CEA), for prevention of stroke, is unclear. The aim was to assess long-term outcomes after CAS, compared with CEA, in a nationwide cohort study.
Methods:
All patients registered in the national Swedish Vascular Registry (Swedvasc) treated with primary CAS between 2005 and 2012 were identified. For every CAS, 2 CEA controls, matched for sex, age, procedure year, and indication (symtomatic/asymtomatic), were chosen. Postoperative stroke was identified by cross-matching the cohort with the InPatient Registry and charts review. Primary end point was ipsilateral stroke or death >30 days postoperatively.
Results:
A total of 1157 patients were included, 409 CAS and 748 CEA; 73% men with mean age 70 years and 69% were symptomatic. Risk factor profile was similar between the 2 groups. Median follow-up time was 4.1 years. Ipsilateral stroke or death of >30 days postoperatively occurred in 95 of 394 in the CAS group versus 120 of 724 in the CEA group (adjusted hazard ratio, 1.59; 95% confidence interval, 1.15-2.18). The corresponding adjusted rates for death, ipsilateral stroke of >30 days, and any stroke or death of >30 days were 25.7% versus 18.6% (hazard ratio, 1.20; 95% confidence interval, 0.84-1.72), 9.4% versus 2.9% (hazard ratio, 3.40; 95% confidence interval, 1.53-7.53), 34.2% versus 23.6% (hazard ratio, 1.49; 95% confidence interval, 1.10-2.00) for the CAS group versus CEA group, respectively.
Conclusions:
In this nationwide cohort study, CAS was associated with an increased long-term risk of ipsilateral stroke and death during after the perioperative phase when compared with CEA.
