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[NO and cancer: itinerary of a double agent]

Stéphanie Plenchette1, Sabrina Romagny1, Véronique Laurens1

  • 1Université de Bourgogne Franche-Comté, LIIC EA7269, 7, boulevard Jeanne d'Arc, F-21000 Dijon, France - EPHE, PSL Research University, F-75014 Paris, France.

Medecine Sciences : M/S
|July 14, 2016
PubMed

Insights

Protein S-nitrosylation, a key regulatory mechanism, influences cell death and tumor growth. Understanding these S-nitrosylated proteins offers potential for novel cancer therapies.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cancer Research

Background:

  • Protein S-nitrosylation is a widespread post-translational modification crucial for cellular processes.
  • This modification plays a dual role in cancer, either promoting tumor growth or inducing cell death.

Purpose of the Study:

  • To review the current understanding of S-nitrosylated proteins involved in oncogenic and apoptotic signaling pathways.
  • To identify proteins with potential therapeutic value in cancer treatment.

Main Methods:

  • Literature review of studies on protein S-nitrosylation in cancer.
  • Analysis of signaling pathways involving S-nitrosylated proteins in oncogenesis and apoptosis.

Main Results:

  • S-nitrosylation significantly impacts tumor progression and cell death.
  • Emerging therapeutic strategies utilize nitric oxide (NO) donors, though their precise cellular mechanisms require further elucidation.
  • Several S-nitrosylated proteins are implicated in cancer signaling.

Conclusions:

  • S-nitrosylation is a critical regulator in cancer biology.
  • Further research into S-nitrosylated proteins may lead to the development of targeted cancer therapies.

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