Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

2.2K
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
2.2K
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

85.9K
Overview
85.9K
Tissue Transplantation01:24

Tissue Transplantation

1.2K
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
1.2K
Hypersensitivity Reactions: Cytolytic Reactions01:01

Hypersensitivity Reactions: Cytolytic Reactions

89
Type II hypersensitivity involves IgG and IgM antibodies targeting cell surface antigens, leading to cell destruction. This can occur through complement activation, antibody-dependent cell-mediated cytotoxicity (ADCC), or acting as opsonins for phagocytosis. When excessive, these reactions cause significant tissue damage.Drug-induced hemolytic anemia is a common example, where drugs like penicillin or cephalosporins bind to red blood cells, forming drug-protein complexes. These complexes...
89

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Multidrug Resistance in Acute Leukaemia: A Comparative Study of Immunocytochemical and RNA Slot Blot Detection of P-glycoprotein Expression.

Leukemia & lymphoma·2016
Same author

Intracoronary platelet and monocyte activation status within platelet-monocyte complexes are determinants of inflammation in ST elevation myocardial infarction1.

Clinical hemorheology and microcirculation·2016
Same author

Generation of memory T cells for adoptive transfer using clinical-grade anti-CD62L magnetic beads.

Bone marrow transplantation·2015
Same author

Tissue-Engineered Tracheal Replacement in a Child: A 4-Year Follow-Up Study.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2015
Same author

Pilot study of a novel vacuum-assisted method for decellularization of tracheae for clinical tissue engineering applications.

Journal of tissue engineering and regenerative medicine·2015
Same author

Tissue banking in ENT: challenges and methods.

The Journal of laryngology and otology·2013
Same journal

Raloxifene inhibits the proliferation of pediatric acute myeloid leukemia by targeting the ANP32B gene and regulating C-MYC expression.

Hematology (Amsterdam, Netherlands)·2026
Same journal

Characterization of a novel α-thalassemia deletion (Dongxing deletion; --<sup>DX</sup>) by CNV-seq in a Chinese female with Hb H disease: a case report.

Hematology (Amsterdam, Netherlands)·2026
Same journal

Real-world pegcetacoplan treatment of paroxysmal nocturnal hemoglobinuria patients with an unsatisfactory response to prior therapies.

Hematology (Amsterdam, Netherlands)·2026
Same journal

Distinct clinical, molecular, and treatment response profiles in primary and secondary myelofibrosis: a single-center retrospective study.

Hematology (Amsterdam, Netherlands)·2026
Same journal

Sirolimus-based treatment regimens for antinuclear antibody (ANA)-positive immune thrombocytopenia: a retrospective single-center cohort study.

Hematology (Amsterdam, Netherlands)·2026
Same journal

Relationship between major depressive disorder and venous thromboembolism: a five-ancestry genetic analysis.

Hematology (Amsterdam, Netherlands)·2026
See all related articles

Related Experiment Video

Updated: Mar 18, 2026

Bone Marrow Transplantation Platform to Investigate the Role of Dendritic Cells in Graft-versus-Host Disease
08:05

Bone Marrow Transplantation Platform to Investigate the Role of Dendritic Cells in Graft-versus-Host Disease

Published on: March 17, 2020

8.4K

Understanding the Graft-Versus-Leukaemia Reaction.

M W Lowdell1, R Craston1, H G Prentice1

  • 1a Department of Haematology , Royal Free Hospital School of Medicine , London , UK.

Hematology (Amsterdam, Netherlands)
|July 14, 2016
PubMed
Summary
This summary is machine-generated.

The immune system plays a crucial role in curing leukemia after allogeneic bone marrow transplants (BMT). Understanding graft-versus-leukemia (GvL) mechanisms is key to developing effective leukemia immunotherapies.

Keywords:
GvHDGvLLeukaemiaimmunotherapy

More Related Videos

Rapid in vivo Drug Response Prediction Using Leukemia Cell Grafts in Zebrafish Embryos
10:46

Rapid in vivo Drug Response Prediction Using Leukemia Cell Grafts in Zebrafish Embryos

Published on: May 23, 2025

1.1K
Murine Model of Leukemia Relapse to Induction Chemotherapy for Acute Lymphoblastic Leukemia
08:31

Murine Model of Leukemia Relapse to Induction Chemotherapy for Acute Lymphoblastic Leukemia

Published on: October 17, 2025

808

Related Experiment Videos

Last Updated: Mar 18, 2026

Bone Marrow Transplantation Platform to Investigate the Role of Dendritic Cells in Graft-versus-Host Disease
08:05

Bone Marrow Transplantation Platform to Investigate the Role of Dendritic Cells in Graft-versus-Host Disease

Published on: March 17, 2020

8.4K
Rapid in vivo Drug Response Prediction Using Leukemia Cell Grafts in Zebrafish Embryos
10:46

Rapid in vivo Drug Response Prediction Using Leukemia Cell Grafts in Zebrafish Embryos

Published on: May 23, 2025

1.1K
Murine Model of Leukemia Relapse to Induction Chemotherapy for Acute Lymphoblastic Leukemia
08:31

Murine Model of Leukemia Relapse to Induction Chemotherapy for Acute Lymphoblastic Leukemia

Published on: October 17, 2025

808

Area of Science:

  • Immunology
  • Hematology
  • Oncology

Background:

  • The role of immune responses in leukemia control and eradication is debated, but evidence suggests immune mediation in cure after chemotherapy and allogeneic bone marrow transplantation (BMT).
  • Reduced leukemia relapse rates after allogeneic BMT compared to autologous or syngeneic BMT, and increased relapse after aggressive graft-versus-host disease (GvHD) prophylaxis, support immune-mediated control.
  • The strong association between GvHD and graft-versus-leukemia (GvL) activity suggests a link, though GvL may be distinct from GvHD.

Purpose of the Study:

  • To explore the immune mechanisms underlying leukemia control and cure, particularly after allogeneic BMT.
  • To elucidate the lymphocyte subsets and target antigens involved in GvL activity.
  • To review the progress and future potential of leukemia immunotherapy.

Main Methods:

  • Review of existing literature on allogeneic BMT, GvHD, and GvL.
  • Analysis of observations regarding leukemia relapse rates in different BMT settings.
  • Discussion of ongoing research into lymphocyte subsets and target antigens for GvL.

Main Results:

  • Allogeneic BMT shows a reduced risk of leukemia relapse compared to other BMT types, indicating immune-mediated effects.
  • Certain immune cells, including T cells, natural killer cells, and in vivo activated killer cells, are implicated in GvL.
  • Research has identified leukemia-specific peptides, such as BCR/ABL in CML, as potential targets for GvL.

Conclusions:

  • The immune system, particularly through GvL activity, is a principal mechanism for achieving leukemia cure post-allogeneic BMT.
  • Further research is needed to fully understand and harness the distinct components of GvL for therapeutic benefit.
  • Advances in understanding immunity, molecular biology, and virology promise to revolutionize leukemia immunotherapy.