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Related Experiment Video

Updated: Mar 18, 2026

Atomic Absorbance Spectroscopy to Measure Intracellular Zinc Pools in Mammalian Cells

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Serum Zinc Levels in Cutaneous Disorders.

P N Arora¹, K S Dhillon², S R Rajan³

¹Ex DDG (PRO), Office of the DGAFMS, New Delhi-110 005.

Medical Journal, Armed Forces India

|July 14, 2016

Summary

This summary is machine-generated.

Serum zinc levels are significantly lower in patients with acne vulgaris, leprosy, and psoriasis compared to healthy individuals. This finding suggests a potential role for zinc in these common skin conditions.

Keywords:

Acne vulgaris Aphthous ulcers Leprosy Psoriasis Vitiligo Zinc

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Area of Science:

Dermatology
Nutritional Science
Biochemistry

Background:

Zinc is an essential trace element crucial for skin health and immune function.
Deficiencies in zinc have been anecdotally linked to various dermatological conditions.
Understanding zinc levels in different skin disorders can inform potential therapeutic strategies.

Purpose of the Study:

To investigate and compare serum zinc levels in patients diagnosed with various cutaneous disorders against healthy controls.
To determine if specific dermatological conditions are associated with statistically significant alterations in serum zinc concentrations.

Main Methods:

A case-control study was conducted involving 75 patients with diverse skin conditions and 24 healthy controls.
Serum zinc levels were quantified using a standardized laboratory method (e.g., atomic absorption spectrophotometry or ICP-MS).
Statistical analysis (e.g., t-tests, ANOVA) was employed to compare mean serum zinc levels between groups.

Main Results:

Serum zinc levels were significantly lower in patients with acne vulgaris (71.5 ± 21.5 µgm/100ml), leprosy (85.9 ± 26.9 µgm/100ml), and psoriasis (93.3 ± 25.9 µgm/100ml) compared to healthy controls (105.3 ± 30.1 µgm/100ml).
No significant differences in serum zinc levels were observed for vitiligo (97.3 ± 26.6 µgm/100ml) and aphthous ulcers (105.2 ± 23.5 µgm/100ml) when compared to controls.
The data indicates a specific association between reduced serum zinc and inflammatory dermatoses like acne, leprosy, and psoriasis.

Conclusions:

Reduced serum zinc levels are significantly associated with acne vulgaris, leprosy, and psoriasis.
These findings highlight the potential role of zinc in the pathogenesis or management of these specific cutaneous disorders.
Further research is warranted to explore the therapeutic implications of zinc supplementation in patients with these conditions.