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Growth in Children with Steroid Sensitive Nephrotic Syndrome

K R Mohan1, M Kanitkar2

  • 1Graded Specialist (Pediatrics), MH Allahabad, UP:-211001.

Medical Journal, Armed Forces India
|July 14, 2016
PubMed

Insights

Steroid treatment for childhood nephrotic syndrome can cause growth retardation. Higher cumulative steroid doses in children with steroid-sensitive nephrotic syndrome correlate with more significant growth impairment.

Area of Science:

  • Pediatric Nephrology
  • Endocrinology
  • Growth and Development

Background:

  • Nephrotic syndrome is common in children aged 2-8 years.
  • Steroids are the primary treatment for nephrotic syndrome.
  • Relapsing cases raise concerns about growth impacts.

Purpose of the Study:

  • To investigate the relationship between cumulative steroid dose and growth in children with steroid-sensitive nephrotic syndrome (SSNS).

Main Methods:

  • Retrospective analysis of 35 children with SSNS.
  • Divided into two groups: steroids only, and steroids with other medications.
  • Measured height and calculated SD scores over one year, correlating growth rate with cumulative steroid dose.

Main Results:

  • A negative correlation was observed between cumulative steroid dose and growth rate (Pearson's r = -0.341).
  • This "fair correlation" indicates that increased steroid dosage is associated with greater growth retardation.
  • Group I (steroids only) showed a stronger correlation (r = -0.441) than Group II.

Conclusions:

  • Growth retardation is directly proportional to the cumulative steroid dose in children with SSNS.
  • This highlights the need for careful steroid management to balance efficacy and growth.
  • Further research may explore strategies to mitigate steroid-induced growth issues.
Abstract

Keywords:
Cumulative doseGrowthNephrotic syndromeSteroids

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