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Related Concept Videos

Glaucoma: Overview01:25

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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
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Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
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Related Experiment Video

Updated: Mar 18, 2026

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Technology and the Glaucoma Suspect.

Dana M Blumberg1, Carlos Gustavo De Moraes1, Jeffrey M Liebmann1

  • 1Bernard and Shirlee Brown Glaucoma Research Laboratory, Department of Ophthalmology, Edward S. Harkness Eye Institute, Columbia University Medical Center, New York, New York, United States.

Investigative Ophthalmology & Visual Science
|July 14, 2016
PubMed
Summary
This summary is machine-generated.

Spectral-domain optical coherence tomography (SD-OCT) demonstrated superior diagnostic performance in identifying early glaucoma compared to visual fields and disc photography. SD-OCT showed better agreement with expert consensus, highlighting its potential as a standalone diagnostic tool for glaucoma suspects.

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Area of Science:

  • Ophthalmology
  • Medical Imaging
  • Diagnostic Technology

Background:

  • Glaucoma diagnosis relies on multiple tests, but differentiating early glaucoma from suspects can be challenging.
  • Assessing the individual diagnostic performance of key tests is crucial for refining clinical practice.

Purpose of the Study:

  • To compare the diagnostic accuracy of spectral-domain optical coherence tomography (SD-OCT), stereoscopic disc photographs, and automated perimetry.
  • To evaluate these tests' ability to differentiate early glaucoma from glaucoma suspects when used individually.

Main Methods:

  • Forty-six eyes with suspicious optic nerves underwent SD-OCT, visual field testing (VF), and optic disc photography.
  • Four glaucoma specialists individually assessed each test's results.
  • Diagnostic performance was compared against a reference standard established by a consensus panel.

Main Results:

  • Spectral-domain optical coherence tomography (SD-OCT) showed the highest discriminative ability (AUC 0.99), outperforming disc photography (AUC 0.85) and VF (AUC 0.86).
  • Interobserver agreement was moderate for SD-OCT (κ=0.40) but poor for VF (κ=0.13) and photographs (κ=0.16).
  • SD-OCT demonstrated better internal agreement and agreement with the expert consensus panel.

Conclusions:

  • SD-OCT, when used alone, offers superior diagnostic performance for early glaucoma detection compared to VF and disc photography.
  • SD-OCT shows better consistency among clinicians and aligns more closely with expert consensus.
  • Further research is recommended to establish optimal interpretation protocols for SD-OCT in glaucoma diagnosis.