Related Experiment Video

Updated: Mar 17, 2026

Implantation of Total Artificial Heart in Congenital Heart Disease
07:27

Implantation of Total Artificial Heart in Congenital Heart Disease

Published on: July 18, 2014

25.3K

Clinical Course After Cardioverter-Defibrillator Implantation: Chagasic Versus Ischemic Patients

Francisca Tatiana Moreira Pereira1, Eduardo Arrais Rocha1, Marcelo de Paula Martins Monteiro1

  • 1Setor de Cardiologia, Hospital Universitário Walter Cantídio, Universidade Federal do Ceará, Fortaleza, CE, Brazil.

Arquivos Brasileiros De Cardiologia
|July 14, 2016
PubMed

Insights

Patients with chronic Chagas cardiomyopathy (CCC) receiving implantable cardioverter defibrillators (ICDs) experienced double the rate of appropriate therapies compared to ischemic heart disease (IHD) patients. However, overall survival and event-free survival did not significantly differ between groups.

Area of Science:

  • Cardiology
  • Electrophysiology
  • Infectious Diseases

Background:

  • The efficacy and outcomes of implantable cardioverter defibrillators (ICDs) in patients with Chagas cardiomyopathy remain debated.
  • Chronic Chagas cardiomyopathy (CCC) presents unique challenges in arrhythmia management.

Purpose of the Study:

  • To compare the clinical outcomes of ICD implantation in patients with CCC versus those with ischemic heart disease (IHD).
  • To evaluate differences in survival rates, event-free survival, and therapy delivery between the two patient groups.

Main Methods:

  • A prospective study involving 153 patients (65 with CCC, 88 with IHD) who received ICDs between 2003 and 2011.
  • Comparison of survival rates and event-free survival between the CCC and IHD cohorts.
  • Analysis of demographic, clinical characteristics, and device-related events.

Main Results:

  • While IHD patients were older, groups were comparable in sex, functional class, and ejection fraction.
  • CCC patients experienced a significantly higher incidence of appropriate shocks and 2.07 times more appropriate therapies.
  • No significant differences were observed in annual mortality, electrical storm incidence, survival time, or event-free survival between CCC and IHD patients.

Conclusions:

  • Chronic Chagas cardiomyopathy patients exhibit a doubled risk of receiving appropriate ICD therapies, indicating more complex arrhythmias.
  • Despite higher therapy rates, CCC patients demonstrated comparable survival outcomes to IHD patients post-ICD implantation.
  • These findings highlight the need for tailored arrhythmia management strategies in Chagas disease.
Abstract

More Related Videos

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing12:45

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

11.1K
Real-Time Cardiac Mapping with a Noninvasive Imageless Electrocardiographic Imaging System10:17

Real-Time Cardiac Mapping with a Noninvasive Imageless Electrocardiographic Imaging System

Published on: April 11, 2025

2.1K

Related Concept Videos

Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
725
Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
584
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
627
Cardiomyopathy I: Introduction and Classification01:25

Cardiomyopathy I: Introduction and Classification

Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
753
Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations01:19

Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations

The pathophysiology of Acute Coronary Syndrome [ACD] involves several key processes:The main underlying cause of ACD is atherosclerosis, a chronic inflammatory disease characterized by the buildup of lipid-laden plaques within the coronary arteries.As the atherosclerotic plaque grows in the coronary artery, it may become unstable due to the formation of a lipid-rich core and a thin fibrous cap. Inflammatory cells within the plaque, such as macrophages, secrete enzymes that degrade the...
637
ECG Interpretation of Arrhythmias II: Atrial, Junctional and Ventricular Arrhythmias01:25

ECG Interpretation of Arrhythmias II: Atrial, Junctional and Ventricular Arrhythmias

Arrhythmia is a condition characterized by an irregular heart rhythm, with ECG changes that differ based on its origin and nature. The types of arrhythmias discussed below include atrial, junctional, and ventricular arrhythmias.Atrial ArrhythmiasPremature Atrial Complexes (PACs): PACs are early atrial beats caused by stress, caffeine, alcohol, electrolyte imbalances, hypoxia, hyperthyroidism, or certain medications (e.g., bronchodilators and decongestants). The ECG shows early P waves with an...
814