Related Experiment Video

Updated: Mar 17, 2026

Pre-clinical Evaluation of Tyrosine Kinase Inhibitors for Treatment of Acute Leukemia
10:49

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Published on: September 18, 2013

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RIPK3 Slams the Brake on Leukemogenesis

Francis Ka-Ming Chan1

  • 1Department of Pathology, Immunology and Microbiology Program, University of Massachusetts Medical School, 368 Plantation Street, Worcester, MA 01605, USA.

Cancer Cell
|July 15, 2016
PubMed

Insights

Cancer cells evade death, but RIPK3, a necroptosis kinase, plays a key role in preventing acute myeloid leukemia development, according to new research.

Area of Science:

  • Oncology
  • Cell Biology
  • Molecular Biology

Background:

  • Cancer cells exhibit a key characteristic of evading cell death pathways.
  • Necroptosis is a regulated form of inflammatory cell death.
  • Acute myeloid leukemia (AML) is a cancer of the blood and bone marrow.

Purpose of the Study:

  • To investigate the role of receptor-interacting protein kinase 3 (RIPK3) in the development of acute myeloid leukemia.
  • To understand how RIPK3 influences cancer cell death evasion.

Main Methods:

  • The study identified RIPK3 as a crucial kinase involved in necroptosis.
  • Researchers examined the function of RIPK3 in the context of acute myeloid leukemia development.

Main Results:

  • RIPK3 was found to be essential in inhibiting the development of acute myeloid leukemia.
  • The kinase activity of RIPK3 is critical for its tumor-suppressive function in AML.

Conclusions:

  • RIPK3 plays a significant role in preventing the initiation and progression of acute myeloid leukemia.
  • Targeting RIPK3 or modulating necroptosis pathways may offer novel therapeutic strategies for AML.

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