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Vaccinations

Vaccinations

Rous Sarcoma Virus (RSV) and Cancer

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Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
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Immunodeficiency Diseases

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Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
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Related Experiment Video

Updated: Mar 17, 2026

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo

Published on: January 7, 2019

Measles.

Paul A Rota¹, William J Moss², Makoto Takeda³

¹Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, Georgia 30329, USA.

Nature Reviews. Disease Primers

|July 15, 2016

Summary

This summary is machine-generated.

Measles is a contagious viral illness causing fever and rash. High vaccination coverage is crucial for measles eradication, despite ongoing global transmission and significant childhood mortality.

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Area of Science:

Virology
Immunology
Public Health

Background:

Measles, caused by the measles virus (MeV), was a near-universal childhood illness before vaccination.
Symptoms include fever, rash, cough, coryza, and conjunctivitis, with potential severe sequelae like pneumonia and encephalitis.

Observation:

Measles virus (MeV) infection leads to immunosuppression, increasing susceptibility to secondary infections.
Diagnosis relies on clinical presentation and laboratory confirmation, such as detecting anti-MeV IgM antibodies or viral RNA.

Findings:

Live attenuated measles vaccines have significantly reduced disease incidence globally.
Despite progress, endemic measles transmission persists worldwide, causing over 100,000 childhood deaths annually.

Implications:

Measles eradication is a global health goal, achievable through high vaccination coverage and robust surveillance.
The availability of an effective vaccine, MeV's monotypic nature, and lack of an animal reservoir make measles a prime candidate for global eradication.