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Updated: Mar 17, 2026

Quantifying Cognitive Decrements Caused by Cranial Radiotherapy

Quantifying Cognitive Decrements Caused by Cranial Radiotherapy

Published on: October 18, 2011

Does cognitive decline decrease health utility value in older adult patients with cancer?

Tatsuo Akechi^1,2, Sayo Aiki¹, Koji Sugano¹

¹Department of Psychiatry and Cognitive-Behavioral Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.

Psychogeriatrics : the Official Journal of the Japanese Psychogeriatric Society

|July 15, 2016

Summary

Cognitive decline in older cancer patients may affect their health utility. However, this association is not independent, with physical condition being a significant factor.

Keywords:

cognitive decline health utility value oncology quality of life

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Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach

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Published on: February 14, 2014

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Quantifying Cognitive Decrements Caused by Cranial Radiotherapy

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Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach

Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach

Published on: February 14, 2014

Area of Science:

Geriatric Oncology
Neuro-oncology
Health Economics

Background:

Cognitive decline is a prevalent issue in older adults diagnosed with cancer.
Health utility value is a crucial measure of quality of life in this population.

Purpose of the Study:

To investigate the impact of cognitive decline on health utility value among older cancer patients.
To identify factors influencing health utility in this demographic.

Main Methods:

Recruited patients aged 65+ with malignant lymphoma or multiple myeloma.
Assessed cognitive function using the Mini-Mental State Examination and health utility with the EuroQoL-5 (EQ-5D) scale.
Employed univariate and multivariate regression analyses to examine associations and control for confounders.

Main Results:

29% of 87 older cancer patients exhibited cognitive decline.
Initially, cognitive decline was linked to lower EQ-5D scores (0.67 vs 0.79).
Multivariate analysis revealed cognitive decline was not independently associated with EQ-5D scores; female sex and poorer physical condition were significant factors.

Conclusions:

While cognitive decline may play a role in reduced health utility for older cancer patients, it is not an independent predictor.
Physical condition emerges as a significant confounding factor influencing health utility in this group.