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Updated: Mar 17, 2026
Author Spotlight: Advancing 3D Modeling for Enhanced Diagnosis and Treatment of Pulmonary Nodules in Early-Stage Lung Cancer
Published on: October 13, 2023
[Lung cancer screening with thoracic X‑ray and CT : Current situation]
O von Stackelberg1,2, H-U Kauczor3,4
1Diagnostische und Interventionelle Radiologe, Universitätsklinikum Heidelberg, Im Neuenheimer Feld 110, 69120, Heidelberg, Deutschland.
Clinical/Methodical Issue:
Attempts at the early detection of lung cancer using imaging methods began as far back as the 1950s.
Standard Radiological Methods:
Several studies attempted to demonstrate a reduction of lung cancer mortality by chest radiography screening but all were unsuccessful.
Methodical Innovations:
Even the first small screening studies using computed tomography (CT) could not demonstrate a reduction in lung cancer-specific mortality until in 2011 the results of the largest randomized controlled low-dose CT screening study in the USA (NLST) were published. The NLST results could show a significant 20 % reduction of lung cancer mortality in elderly and heavy smokers using CT.
Performance:
Confirmation of the NLST results are urgently needed so that the data of the largest European study (NELSON) are eagerly awaited.
Achievements:
Pooled with the data from several smaller European studies these results will provide important information and evidence for the establishment of future CT screening programs in Europe.
Practical Recommendations:
Randomized controlled trials are the basis of evidence-based medicine; therefore, the positive results of the methodologically very good NLST study cannot be ignored, even if it is the only such study completed so far with highly convincing conclusions. The NLST results clearly demonstrate that positive effects for the health of the population can only be expected if the processes are clearly defined and the quality is assured.
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