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[Microvascular changes in COVID-19].

W L Wagner1,2, K Hellbach3,4, M O Fiedler4,5

  • 1Klinik für Diagnostische und Interventionelle Radiologie, Universitätsklinikum Heidelberg, Im Neuenheimer Feld 110, 69120, Heidelberg, Deutschland. willi.wagner@uni-heidelberg.de.

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Summary
This summary is machine-generated.

This study reveals microvascular damage and vasodysregulation in fatal COVID-19, highlighting the importance of correlating autopsy findings with imaging for understanding lung and organ pathologies.

Keywords:
Computed tomographyMicrovesselsPathological correlationPerfusionSARS-CoV‑2

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Area of Science:

  • Pathology
  • Radiology
  • Pulmonology

Background:

  • Coronavirus disease 2019 (COVID-19) presents with diverse symptoms, from mild respiratory issues to severe multi-organ failure.
  • Pulmonary damage in COVID-19 is complex, involving microvascular changes and systemic pathologies beyond initial findings like diffuse alveolar damage.

Purpose of the Study:

  • To investigate microvascular involvement in fatal COVID-19 cases.
  • To correlate radiological imaging with pathological autopsy findings to understand microstructural vascular changes.

Main Methods:

  • Radiological and pathological correlation in two fatal COVID-19 cases.
  • Microradiological imaging to assess microvascular changes.

Main Results:

  • Patient 1 showed subtle microvascular damage in lung regions without typical COVID-19 infiltrates.
  • Patient 2 exhibited advanced lung destruction and blood-air barrier damage; intestinal hypoperfusion was noted but not definitively linked to microvascular damage.
  • Findings suggest both microvascular thrombosis and functional pulmonary vasodysregulation in COVID-19.

Conclusions:

  • COVID-19 pathophysiology involves microvascular thrombosis and pulmonary vasodysregulation.
  • Integrating radiological and histopathological findings from autopsies is crucial for a comprehensive understanding of COVID-19 vascular injury.