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Related Concept Videos

Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

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Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
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Cystic Fibrosis: Management01:24

Cystic Fibrosis: Management

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Cystic fibrosis (CF) is an autosomal recessive disorder that predominantly affects individuals of Northern European descent, occurring at a rate of 1 in 3500. It is caused by a genetic mutation in a gene on chromosome 7, most commonly the ΔF508 mutation, that codes for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. This results in thicker mucus secretions and obstruction pathologies in multiple organs, including the lungs and sinuses.
Sinus disease and chronic...
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Barrett Esophagus-II: Clinical Manifestations and Management01:21

Barrett Esophagus-II: Clinical Manifestations and Management

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Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
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Barrett Esophagus-I: Introduction01:21

Barrett Esophagus-I: Introduction

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Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
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Cystic Fibrosis: Pathogenesis01:23

Cystic Fibrosis: Pathogenesis

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Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
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Gastroesophageal Reflux Disease II: Clinical Features and Management01:29

Gastroesophageal Reflux Disease II: Clinical Features and Management

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Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
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Updated: Mar 17, 2026

Fingerprinting Cardiolipin in Leukocytes by Mass Spectrometry for a Rapid Diagnosis of Barth Syndrome
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Refractory Castleman's Disease.

P Jacobs1, L Wood1, V Jogessar2

  • 1a The Department of Haematology and the Bone Marrow Transplant Unit , Constantiaberg Medi-Clinic , Burnham Road, Plumstead 7800, Cape Town , South Africa.

Hematology (Amsterdam, Netherlands)
|July 15, 2016
PubMed
Summary
This summary is machine-generated.

High-dose chemoradiotherapy with stem cell transplant offers a durable remission for aggressive angiofollicular lymph node hyperplasia. This treatment is a viable option for patients resistant to conventional therapies.

Keywords:
Castleman's diseaseallogeneicbone marrow transplantationcomplete remission

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Area of Science:

  • Hematology
  • Oncology

Background:

  • Angiofollicular lymph node hyperplasia (ALNH) is a rare lymphoproliferative disorder.
  • The plasma cell subtype of ALNH can present with severe systemic symptoms and is often refractory to standard treatments.

Purpose of the Study:

  • To report a successful case of high-dose chemoradiotherapy with allogeneic peripheral blood stem cell transplantation (PBSCT) in a patient with aggressive ALNH.
  • To support PBSCT as a treatment option for refractory ALNH.

Main Methods:

  • The patient received conditioning with total body irradiation, cyclophosphamide, and high-dose melphalan, followed by total nodal irradiation.
  • Allogeneic PBSCT was performed using stem cells from an HLA-compatible sibling.
  • The patient's recovery was complicated by pulmonary tuberculosis.

Main Results:

  • The patient achieved immediate and durable complete remission at one-year follow-up.
  • Despite complications, the treatment was successful in controlling the disease.

Conclusions:

  • High-dose chemoradiotherapy with allogeneic PBSCT is a potentially curative option for aggressive and refractory ALNH.
  • This case adds to the evidence supporting this intensive treatment approach for severe ALNH variants.