[Changes in catalytic properties of membrane-bound monoamine oxidases in alcoholic intoxication]

Chronic alcohol intoxication was accompanied by qualitatively new deamination reactions of cadaverine or glucosamine in dialyzed fraction of rat liver tissue homogenate. The rate of reactions was considerably more distinct in human liver and brain tissues obtained post mortem from patients with chronic alcoholism. At the same time, impairments were observed both in deamination of biogenic monoamines by membrane-bound monoamine oxidases and in ascorbate-dependent lipid peroxidation. The qualitative modifications in catalytic properties of membrane-bound monoamine oxidase, related to reactions of deamination and lipid peroxidation, appear to be of importance in chronic alcoholism and acute lethal alcohol intoxication.