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Phosphodiesterase 5 (PDE5) inhibitors are potent enzymes that function to hydrolyze cyclic nucleotides to their corresponding 5' monophosphates. Their unique biochemical properties have been applied in treating Pulmonary Arterial Hypertension (PAH).
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Supramaximal Intensity Hypoxic Exercise and Vascular Function Assessment in Mice
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Sildenafil does not Improve Exercise Capacity under Acute Hypoxia Exposure.

A H Toro-Salinas1, N Fort1, J R Torrella1

  • 1Departament de Fisiologia i Immunologia, Universitat de Barcelona, Barcelona, Spain.

International Journal of Sports Medicine
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Sildenafil does not improve physical performance in healthy individuals exposed to high altitude. This study found no significant cardiovascular or respiratory benefits during rest or exercise under hypoxic conditions.

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Area of Science:

  • Physiology
  • Pharmacology
  • Sports Science

Background:

  • Hypoxic pulmonary vasoconstriction (HPV) increases pulmonary arterial pressure (PAP), potentially limiting physical performance during hypoxia.
  • Sildenafil's known effect on reducing PAP suggests a potential role as an ergogenic aid or even a doping substance.

Purpose of the Study:

  • To investigate the effects of sildenafil on cardiovascular, respiratory, and metabolic parameters.
  • To assess sildenafil's impact on physical performance in normoxia and hypobaric hypoxia at rest and during exercise.

Main Methods:

  • Double-blind, placebo-controlled crossover study involving 11 healthy volunteers.
  • Administration of 100 mg sildenafil or placebo one hour before testing.
  • Testing included rest, maximal, and submaximal (60% VO2 max) exercise in normoxic and hypobaric hypoxic (4,000m) conditions.

Main Results:

  • Sildenafil did not affect physical performance in normoxic conditions.
  • No significant differences in cardiovascular or respiratory parameters were observed in hypoxic conditions at rest or during exercise.
  • The data does not support the use of sildenafil for enhancing physical performance in non-acclimatized individuals.

Conclusions:

  • Sildenafil does not appear to be an ergogenic aid for physical performance in healthy, non-acclimatized individuals exposed to acute hypobaric hypoxia.
  • Further research may be needed to explore potential effects in different populations or under varying hypoxic conditions.