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Updated: Mar 17, 2026

Targeted Plasma Membrane Delivery of a Hydrophobic Cargo Encapsulated in a Liquid Crystal Nanoparticle Carrier
Published on: February 8, 2017
A Large Capacity Cationic Metal-Organic Framework Nanocarrier for Physiological pH Responsive Drug Delivery
Yanyu Yang1, Quan Hu2, Qi Zhang1
1State Key Laboratory of Silicon Material, Cyrus Tang Center for Sensor Material and Applications, School of Materials Science and Engineering, Zhejiang University , Hangzhou 310027, P.R. China.
Abstract:
A nanoscale cationic porous drug carrier ZJU-101 (ZJU = Zhejiang University), synthesized by the solvothermal method to get the crystal size of ∼300 nm, was used to load diclofenac sodium, an anionic drug. This positively charged host materials showed a large loading capacity of diclofenac sodium (∼0.546 g/g) through ion exchange and penetration procedures. The drug delivery in the inflamed tissues (pH = 5.4) exhibited a more effective release in comparison with that in the normal tissues (pH = 7.4), demonstrating a physiological pH responsive drug release. This discriminating drug release process was controlled by anion exchange between anions in phosphate buttered saline (PBS) and coordinated/free diclofenac anions.
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