Related Experiment Video
Updated: Mar 17, 2026

07:28
JUMPn: A Streamlined Application for Protein Co-Expression Clustering and Network Analysis in Proteomics
Published on: October 19, 2021
3.7K
Topological similarity of random cell complexes and applications
B Schweinhart1, J K Mason2, R D MacPherson3
1Center of Mathematical Sciences and Applications, Harvard University, Cambridge, Massachusetts 02138, USA.
Physical Review. E
|July 15, 2016
Summary
This study introduces novel methods, the swatch and cloth, to quantify topological similarities in cell complexes. This approach enables a general and complete statistical analysis of local topology across physical sciences.
Area of Science:
- Physical Sciences
- Materials Science
- Computational Topology
Background:
- Random cell complexes are prevalent in physical sciences but lack standardized methods for statistical comparison.
- Existing methods are often system-specific and not universally applicable.
- A general framework is needed to analyze and compare the local topology of cell complexes.
Purpose of the Study:
- To develop a general and complete method for quantifying statistical similarities and differences in cell complexes.
- To introduce novel concepts, the swatch and cloth, for describing local cell complex topology.
- To define a distance metric for comparing the local topology of two cell complexes.
Main Methods:
- Introduction of the swatch and cloth as general descriptors of local cell complex topology.
- Development of a distance metric based on the swatch and cloth to measure topological similarity.
- Application of the distance metric to analyze model grain boundary and dislocation networks.
Main Results:
- The swatch and cloth provide a general and complete description of local cell complex topology.
- A novel distance metric effectively quantifies topological similarity between cell complexes.
- The distance metric was used to identify a steady state in a grain boundary network, independent of initial conditions.
- The metric demonstrated that long-term properties of a dislocation network model are independent of intersection implementation.
Conclusions:
- The swatch and cloth offer a universally applicable framework for analyzing cell complex topology.
- The defined distance metric is a powerful tool for comparing complex systems in physical sciences.
- This approach facilitates the study of system dynamics, steady states, and initial condition independence.
More Related Videos
Related Concept Videos
Protein Networks
4.7K
An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
4.7K
Protein Complex Assembly
17.0K
Proteins can form homomeric complexes with another unit of the same protein or heteromeric complexes with different types. Most protein complexes self-assemble spontaneously via ordered pathways, while some proteins need assembly factors that guide their proper assembly. Despite the crowded intracellular environment, proteins usually interact with their correct partners and form functional complexes.
Many viruses self-assemble into a fully functional unit using the infected host cell to...
Many viruses self-assemble into a fully functional unit using the infected host cell to...
17.0K
Protein Complexes with Interchangeable Parts
3.0K
Groups of proteins may form a complex where each protein in this complex has a different role in the overall execution of the complex’s function. Often some of the proteins in the complex can be replaced by a closely related variant to give a complex that contains many of the same components yet is functionally distinct.
The SCF ubiquitin ligase is a protein complex of five individual proteins. This complex attaches ubiquitin to other target proteins to mark them for degradation. In order...
The SCF ubiquitin ligase is a protein complex of five individual proteins. This complex attaches ubiquitin to other target proteins to mark them for degradation. In order...
3.0K
Assembly of Complex Microtubule Structures
2.8K
Complex microtubule structures are present in resting cells and in dividing cells. In resting cells, they are responsible for maintaining the cellular architecture, tracks for intracellular transport, positioning of organelles, assembly of cilia and flagella. They mediate the bipolar spindle assembly for chromosomal segregation and positioning of the cell division plate in dividing cells. The formation of microtubule complex structures depends on the cell type, cell stage, and cell function.
2.8K

