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Norepinephrine Injection into the Paraventricular Nucleus Induces a Reduced Modification of Eating Behavior and
M Monda1, R Sperandeo1, A Viggiano1
1a Department of Human Physiology and Integrated Biological Functions "F. Bottazzi" , Second University of Naples , Via Costantinopoli 16, I-80138, Naples , Italy.
Abstract:
Intake of carbohydrates, lipids, proteins and total calories, temperature of interscapular brown adipose tissue, and oxygen consumption were monitored in vasopressin-containing and vasopressin-deficient rats. These variables were measured after a 20 nmol norepinephrine (NE) or saline injection into the paraventricular nucleus (PVN) of the hypothalamus. NE increased the intake of carbohydrates, lipids and total calories, decreased brown adipose tissue temperature and oxygen consumption in vasopressin-containing rats. NE reduced the intake of carbohydrates, while it increased the consumption of lipids in vasopressin-deficient rats. These findings indicate that vasopressin is involved in the modifications of eating behavioral and thermogenesis induced by NE injection into the hypothalamic PVN.
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