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Spanish Validation of the Problem Behaviors Assessment-Short (PBA-s) for Huntington's Disease
Jesús M Ruiz-Idiago1, Misericordia Floriach1, Cèlia Mareca1
1From the Huntington Disease Programme, Hospital Mare de Déu de la Mercè, Hermanas Hospitalarias, Barcelona, Spain (JR-I, MF, PR); the FIDMAG Hermanas Hospitalarias Research Foundation, Barcelona, Spain (RS, EP-C, SS); the Programa de Doctorat de Psiquiatria, Universitat Autònoma de Barcelona, Barcelona, Spain (JR-I); the CIBERSAM, Instituto de Salud Carlos III, Madrid, Spain (RS, EP-C, SS); the Neurology Department, Hospital Ramón y Cajal, Madrid, Spain (JL-S, VM); the Instituto Ramón y Cajal de Investigación Sanitaria, Madrid, Spain (JL-S, VM); the CIBERNED, Instituto de Salud Carlos III, Madrid, Spain (JL-S); the Neurology Department, Complejo Asistencial Universitario Burgos, Burgos (EB), Spain; the Neurology Department, Movement Disorders Unit, Fundació Clinic per la Recerca Biomèdica, Barcelona, Spain (EM, PS, LV); and the Dementia Unit, Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain (MN).
Abstract:
A prospective, observational multicenter study was carried out assessing neuropsychiatric symptoms in a sample of 117 subjects in order to validate the Spanish version of the Problem Behaviors Assessment-Short (PBA-s). The psychometric properties of this version were analyzed. Inter- and intra-rater reliability were good: the mean weighted Cohen's kappa was 0.90 for severity scores and 0.93 for frequency scores. Four factors accounting for 56% of the total variance were identified after an exploratory factor analysis: apathy, irritability, depression, and perseveration. The PBA-s correlates strongly with the Neuropsychiatric Inventory, demonstrating its accuracy for assessing neuropsychiatric symptoms in patients with Huntington's disease.
