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Chronic periodontitis is associated with lacunar infarct: a case-control study
Y Leira1,2, I López-Dequidt3, S Arias3
1Department of Periodontology, School of Dentistry, Faculty of Medicine, University of Santiago de Compostela, Santiago de Compostela, Spain. yagoleira@gmail.com.
European Journal of Neurology
|July 16, 2016
Summary
Chronic periodontitis is significantly linked to lacunar infarct in the elderly. This study found a strong association between gum disease and stroke, even after accounting for common vascular risk factors.
Area of Science:
- Gerontology
- Cardiovascular Health
- Oral Health
Background:
- Chronic periodontitis (ChP) and lacunar infarct (LI) are prevalent conditions in older adults.
- Existing research links ischemic stroke with ChP, but the ChP-LI relationship is less understood.
Purpose of the Study:
- To investigate the association between chronic periodontitis and the presence of lacunar infarct.
- To determine if ChP is an independent risk factor for LI.
Main Methods:
- An age- and gender-matched case-control study.
- Involved 62 subjects with LI (cases) and 60 controls.
- Assessed periodontal measures and risk factors via questionnaire.
Main Results:
- ChP showed a strong association with LI (OR 4.20, P=0.001) after adjusting for vascular risk factors.
- Severe ChP also demonstrated a significant association with LI (OR 3.53, P=0.04), independent of other covariates.
Conclusions:
- Chronic periodontitis is independently associated with lacunar infarct in the elderly.
- Further research is needed to elucidate the underlying pathophysiological mechanisms.
