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Updated: Mar 17, 2026

Combining Chemical Cross-linking and Mass Spectrometry of Intact Protein Complexes to Study the Architecture of Multi-subunit Protein Assemblies
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Mass spectrometry locates local and allosteric conformational changes that occur on cofactor binding

Rebecca Beveridge1, Lukasz G Migas1, Karl A P Payne1

  • 1Michael Barber Centre for Collaborative Mass Spectrometry, School of Chemistry, Centre for Synthetic Biology of Fine and Speciality Chemicals, Manchester Institute of Biotechnology, University of Manchester, 131 Princess Street, Manchester M1 7DN, UK.

Nature Communications
|July 16, 2016
PubMed
Summary

The Fdc1 enzyme

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