Mean Platelet Volume in Mycobacterium tuberculosis Infection

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Polarization of M1 and M2 Human Monocyte-Derived Cells and Analysis with Flow Cytometry upon Mycobacterium tuberculosis Infection
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Polarization of M1 and M2 Human Monocyte-Derived Cells and Analysis with Flow Cytometry upon Mycobacterium tuberculosis Infection

Published on: September 18, 2020

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Min Young Lee1, Young Jin Kim2, Hee Joo Lee2

  • 1Department of Laboratory Medicine, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea; Department of Laboratory Medicine, School of Medicine, Kyung Hee University, Seoul 02447, Republic of Korea.

Biomed Research International
|July 16, 2016
PubMed

Insights

Mean platelet volume (MPV) can serve as an inflammatory marker for tuberculosis (TB). This study found a significant correlation between MPV and C-reactive protein (CRP) in TB patients, indicating its potential role in assessing disease activity.

Area of Science:

  • Hematology
  • Infectious Diseases
  • Pulmonology

Background:

  • Mean platelet volume (MPV) is recognized as an indicator of platelet activation.
  • MPV is potentially linked to various inflammatory and infectious conditions.
  • Tuberculosis (TB) remains a significant public health concern with a high incidence in Korea.

Purpose of the Study:

  • To evaluate the utility of MPV as an inflammatory marker in patients diagnosed with TB.
  • To investigate the relationship between MPV and inflammatory markers in TB.

Main Methods:

  • MPV levels were measured in 221 TB patients and 143 healthy controls.
  • Platelet volume was assessed using the Advia 2120 analyzer.
  • Correlations between MPV, C-reactive protein (CRP), and age were analyzed in TB patients.

Main Results:

  • A positive correlation was observed between CRP levels and MPV in the TB patient cohort.
  • A positive correlation was also found between age and MPV among TB patients.
  • These findings suggest a link between MPV and inflammatory status in TB.

Conclusions:

  • MPV demonstrates a significant association with inflammatory conditions.
  • MPV may function as a valuable inflammatory marker for monitoring disease activity in TB patients.
  • Further research can explore MPV's role in TB management.

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