Related Experiment Video
Updated: Mar 17, 2026
07:32
Phagosome Migration and Velocity Measured in Live Primary Human Macrophages Infected with HIV-1
Published on: September 5, 2016
8.7K
Hemophagocytic Syndrome Induced by HIV
C Alliot1, M Barrios2, M Brunel1
1a Department of Internal Medicine , Saint-Eloi University Hospital , 2 Avenue Bertin-Sans, 34 295 Montpellier Cedex 5, France.
Hematology (Amsterdam, Netherlands)
|July 16, 2016
Summary
Severe hemophagocytic syndrome (HPS) in adults with HIV infection can be fatal. This case suggests HIV itself may cause HPS, even without opportunistic infections, highlighting a poor prognosis.
Area of Science:
- Immunology
- Hematology
- Infectious Diseases
Background:
- Hemophagocytic syndrome (HPS) involves activated macrophages engulfing blood cells.
- HPS is linked to infections, cancers, and autoimmune conditions.
- Cytokines from lymphocytes drive macrophage activation, potentially causing treatment resistance.
Purpose of the Study:
- To describe a fatal case of severe hemophagocytic syndrome in an adult with HIV infection.
- To investigate potential causes of HPS in the absence of opportunistic diseases.
- To highlight the prognosis of HPS in HIV-infected individuals.
Main Methods:
- Case report of an adult patient with HIV infection and severe HPS.
- Comprehensive evaluation to rule out opportunistic infections and other known causes of HPS.
- Clinical data analysis and outcome assessment.
Main Results:
- The patient presented with severe HPS.
- Extensive investigations did not identify opportunistic diseases or other common HPS triggers.
- The patient's outcome was fatal.
Conclusions:
- Human immunodeficiency virus (HIV) infection may be a direct cause of severe hemophagocytic syndrome.
- HPS in the context of HIV infection carries a poor prognosis.
- Further research is needed to understand the mechanisms of HIV-associated HPS.
Related Concept Videos
01:25Immunodeficiency Diseases
2.7K
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
There are three main causes of immunodeficiency...
2.7K
01:26Sexually Transmitted Infections
1.5K
Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...
1.5K
01:01Hypersensitivity Reactions: Cytolytic Reactions
89
Type II hypersensitivity involves IgG and IgM antibodies targeting cell surface antigens, leading to cell destruction. This can occur through complement activation, antibody-dependent cell-mediated cytotoxicity (ADCC), or acting as opsonins for phagocytosis. When excessive, these reactions cause significant tissue damage.Drug-induced hemolytic anemia is a common example, where drugs like penicillin or cephalosporins bind to red blood cells, forming drug-protein complexes. These complexes...
89
01:24Nephrotic Syndrome I : Introduction
836
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
836