Related Experiment Video
Updated: Mar 17, 2026
12:58
Expression of Exogenous Cytokine in Patient-derived Xenografts via Injection with a Cytokine-transduced Stromal Cell Line
Published on: May 10, 2017
9.9K
The Relevance of Circulating Interleukin-5 (IL-5) in Lymphoproliferative Disorders
D A Aladle1, M A Salem1, L A Mahmoud1
1a Hematology Unit, Clinical Pathology Department, Faculty of Medicine , Mansoura University , Egypt.
Hematology (Amsterdam, Netherlands)
|July 16, 2016
Summary
Interleukin-5 (IL-5) plays a key role in lymphoproliferative disorders (LPDs), influencing disease characteristics and eosinophilia. Elevated IL-5 levels correlate with increased lymphoma grade and tumor burden in patients.
Area of Science:
- Immunology
- Hematology
- Oncology
Background:
- Cytokines regulate neoplastic processes in lymphoproliferative disorders (LPDs).
- The specific role of interleukin-5 (IL-5) in LPD phenotype, progression, and eosinophilia requires clarification.
Purpose of the Study:
- To investigate the role of IL-5 in LPDs.
- To determine IL-5's association with disease phenotype, progression, and eosinophilia in LPD patients.
Main Methods:
- Serum IL-5 concentrations were measured in 49 untreated LPD patients (NHL, CLL, HD) and 14 controls.
- Patients were categorized into Non-Hodgkin Lymphoma (NHL), Chronic Lymphocytic Leukemia (CLL), and Hodgkin Disease (HD) groups.
- Statistical analyses correlated IL-5 levels with clinical parameters like lymphocytic counts, lymphoma grade, and eosinophilia.
Main Results:
- Serum IL-5 levels were statistically significant in LPDs, with the highest concentrations observed in CLL patients.
- In NHL, rising IL-5 levels correlated with increasing lymphoma grade.
- IL-5 concentration showed significant correlations with absolute eosinophilia, absolute lymphocytosis, bone marrow lymphocytosis, and bone marrow infiltration.
Conclusions:
- IL-5 is crucial in generating the neoplastic phenotype of LPDs.
- IL-5 may be responsible for paraneoplastic features, such as eosinophilia, observed in LPDs.
Related Concept Videos
01:27Disorders of Leukocytes
2.3K
Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...
2.3K
01:24T Cell Types and Functions
3.1K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
3.1K
01:15Differentiation of Common Myeloid Progenitor Cells
4.2K
Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
4.2K
01:18Lymphoid Cells and Tissues
3.7K
Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
3.7K
01:01Regulation of Hematopoietic Stem Cells
4.3K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
4.3K
01:28Role of Hematopoietic Growth Factors
4.3K
Hematopoietic growth factors are molecules that regulate the differentiation rate of hematopoietic stem cells (HSCs). Erythropoietin (EPO), primarily produced by the kidneys, plays a crucial role in erythrocyte production. When oxygen levels in the blood are low, EPO is released into the bloodstream, reaching the bone marrow, where it stimulates HSCs to differentiate and mature into erythrocytes, which are vital for oxygen transport.
Thrombopoietin (TPO), mainly released by the liver,...
Thrombopoietin (TPO), mainly released by the liver,...
4.3K