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[Calciphylaxis. A review of 9 cases]
Leire Loidi Pascual1, Ana Valcayo Peñalba1, Saioa Oscoz Jaime1
1Servicio de Dermatología, Complejo Hospitalario de Navarra, Pamplona, España.
Insights
Calciphylaxis, a rare vascular disease, affects older adults with comorbidities. This study highlights the importance of multidisciplinary care and sodium thiosulfate in managing calciphylaxis patients.
Area of Science:
- Dermatology
- Vascular Medicine
- Nephrology
Background:
- Calciphylaxis is a severe vascular disease affecting small vessels, characterized by high morbidity and mortality.
- Limited published data exists, particularly from Spanish hospitals.
- Understanding patient profiles and risk factors is crucial for improved management.
Purpose of the Study:
- To analyze the demographic, clinical, and histological profile of calciphylaxis patients.
- To identify risk factors associated with calciphylaxis.
- To explore potential therapeutic strategies for calciphylaxis.
Main Methods:
- Retrospective study design.
- Inclusion of patients diagnosed with calciphylaxis and confirmed by biopsy.
- Data collected from January 2010 to August 2015.
Main Results:
- Nine patients were studied, aged 76-86 years.
- All patients presented with cardiovascular comorbidities.
- Renal failure was present in 67% of patients, with an observed mortality rate of 33%.
Conclusions:
- Complete blood analysis is essential for differential diagnosis of skin ulcers.
- Multidisciplinary team management is recommended for calciphylaxis patients.
- Sodium thiosulfate shows promise as a therapeutic agent for calciphylaxis.
Background And Objective:
Calciphylaxis is a cutaneous ischaemic vascular disease of small vessels with high morbidity and mortality. To date very few series of patients with this disease have been published, none from a Spanish hospital. The main objectives of this work are to analyze the demographic, clinical and histological profile of patients diagnosed in our department to identify risk factors and potential therapeutic strategies.
Material And Method:
We made a retrospective study of the cases seen in the dermatology department with a diagnosis of calciphylaxis and who had a confirmatory biopsy in the period between January 2010 to August 2015.
Results:
Nine patients were studied, with an age range of 76-86 years. All had cardiovascular comorbidities and 67% had renal failure. A 33% mortality was observed.
Conclusions:
Faced with a possible diagnosis of calciphylaxis, a complete blood analysis is mandatory to rule out other causes of skin ulcers. The management of these patients should be undertaken by a multidisciplinary team. We emphasize the role of sodium thiosulfate in the treatment of this condition.
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