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Outgroups and Positive Selection: The Nothobranchius furzeri Case
Arne Sahm1, Matthias Platzer1, Alessandro Cellerino2
1Leibniz Institute on Aging, Fritz Lipmann Institute, Jena, Germany.
Abstract:
Applications of positive selection analysis increase with the number of species for which genome/transcriptome sequences become available. Using the recently sequenced turquoise killifish (Nothobranchius furzeri) genome as an example, we compare two different approaches based on different outgroup selection. The combination of these two methods allows the origin of positively selected sites in aging-related genes of the N. furzeri genome to be determined.
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