[Modification of eremomycin by amine groups]

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Updated: Aug 19, 2026

The Logic, Experimental Steps, and Potential of Heterologous Natural Product Biosynthesis Featuring the Complex Antibiotic Erythromycin A Produced Through E. coli
10:41

The Logic, Experimental Steps, and Potential of Heterologous Natural Product Biosynthesis Featuring the Complex Antibiotic Erythromycin A Produced Through E. coli

Published on: January 13, 2013

E N Olsuf'eva, T F Berdnikova, N Iu Dokshina

    Antibiotiki I Khimioterapiia = Antibiotics and Chemoterapy [Sic]
    |May 1, 1989
    PubMed

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    In the presence of an aqueous base and a halogen, primary amides can lose the carbonyl (as carbon dioxide) and undergo rearrangement to form primary amines. This reaction, called the Hofmann rearrangement, can produce primary amines (aryl and alkyl) in high yields without contamination by secondary and tertiary amines.
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