A biosynthesis-inspired approach to over twenty diverse natural product-like scaffolds
James D Firth1, Philip G E Craven1, Matthew Lilburn1
1School of Chemistry, University of Leeds, Leeds LS2 9JT, UK. a.s.nelson@leeds.ac.uk s.p.marsden@leeds.ac.uk.
Abstract:
A synthetic approach to diverse scaffolds was developed that was inspired by diterpene biosynthesis. Initial scaffolds, generated using Diels-Alder reactions of furyl-functionalised amines, were transformed into alternative scaffolds using cleavage, ring expansion, annulation and rearrangement reactions. In total, 25 diverse scaffolds were prepared that were shown to have high natural product-likeness.
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