Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Multiple Allele Traits01:49

Multiple Allele Traits

38.6K
The Concept of Multiple Allelism
38.6K
Exercise and Cardiovascular Response01:20

Exercise and Cardiovascular Response

4.9K
Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
4.9K
Exercise Stress Test01:26

Exercise Stress Test

1.7K
Introduction
Exercise stress testing, commonly known as a treadmill test, is a noninvasive procedure used to evaluate cardiovascular function and diagnose heart conditions.
Definition
An exercise stress test measures the heart's response to exertion using a treadmill or stationary bicycle. Chest electrodes record the heart's electrical activity through an ECG, and blood pressure is monitored regularly.
Purposes
1.7K
Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

568
Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
568
Coronary Artery Disease III: Clinical Manifestations01:30

Coronary Artery Disease III: Clinical Manifestations

522
Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
522
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

627
Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
627

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Marathon: Is More Less?

The Physician and sportsmedicine·2016
Same author

The Anemias of Athletes.

The Physician and sportsmedicine·2016
Same author

Sickle Cell Trait, Exercise, and Altitude.

The Physician and sportsmedicine·2016
Same author

The Caffeine Controversy: Effects on Endurance and Cholesterol.

The Physician and sportsmedicine·2016
Same author

Blood Doping: Results and Consequences From the Laboratory and the Field.

The Physician and sportsmedicine·2016
Same author

Arthritis and Aerobic Exercise: A Review.

The Physician and sportsmedicine·2016

Related Experiment Video

Updated: Mar 17, 2026

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy
07:24

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy

2.0K

Sickle Cell Trait, Heroic Exercise, and Fatal Collapse.

E R Eichner

    The Physician and Sportsmedicine
    |July 19, 2016
    PubMed
    Summary

    Sickle cell trait is usually harmless but can cause serious health issues during intense exercise, especially in hot weather or at high altitudes. Awareness and prevention are key to managing these risks.

    Area of Science:

    • Exercise Physiology
    • Hematology
    • Environmental Medicine

    Background:

    • Sickle cell trait (SCT) is generally considered benign and compatible with high-level athletic performance.
    • However, SCT can present risks, including gross hematuria and splenic infarction, particularly at high altitudes.

    Purpose of the Study:

    • To highlight the life-threatening risks associated with SCT during maximal exercise.
    • To describe a severe exertional syndrome linked to SCT.
    • To provide guidance on recognition and prevention of these exertional complications.

    Main Methods:

    • Review of existing literature and case reports.
    • Analysis of clinical presentations and outcomes in individuals with SCT experiencing exertional collapse.

    More Related Videos

    Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry
    08:23

    Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry

    Published on: November 5, 2019

    10.5K
    Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
    05:23

    Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

    Published on: March 14, 2017

    20.6K

    Related Experiment Videos

    Last Updated: Mar 17, 2026

    A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy
    07:24

    A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy

    2.0K
    Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry
    08:23

    Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry

    Published on: November 5, 2019

    10.5K
    Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
    05:23

    Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

    Published on: March 14, 2017

    20.6K

    Main Results:

    • Maximal exercise, especially in hot conditions or at altitude, can trigger a dangerous syndrome in some individuals with SCT.
    • This syndrome includes sickling, rhabdomyolysis, lactic acidosis, collapse, acute kidney injury, and hyperkalemia.
    • Over 30 cases of this severe exertional syndrome have been documented.

    Conclusions:

    • While typically benign, SCT carries a risk of severe, life-threatening exertional complications.
    • Recognition of this syndrome is crucial for timely intervention.
    • Practical strategies for prevention and management are essential for athletes with SCT.