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Updated: Aug 19, 2026

Heterotypic Three-dimensional In Vitro Modeling of Stromal-Epithelial Interactions During Ovarian Cancer Initiation and Progression
Published on: August 28, 2012
Abstract:
The paper provides the results of the examination of ovarian serous borderline tumors in 68 patients followed up during different periods (up to 22 years) after surgery. More valuable information on the course and prognosis of the disease will be provided by taking into account both the process stages and structural features of extra-ovarian implants rather than by detecting the foci of initial invasive growth in the primary tumor. Among 4 peritoneal neoplasia types defined by the author, the desmoplastic reaction occurring around the tubal type tumor cells in particular, should be regarded as the most unfavourable type. The author believes that the serous borderline tumor of the ovary is not a separate nosological entity but a step in progressive malignant transformation of mesothelial tubal epithelium similar to definition of well differentiated carcinoma given by the traditional classification.
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