[Fibroblasts and morphogenesis of tissue components of tumor stroma]

Stereometric, morphohistochemical, and ultrastructural techniques were used to examine fibroblasts and morphogenesis of the stroma in 337 carcinomas of various sites and their metastases. The examination showed that, morphologically, the fibroblasts of the stroma were identical to connective tissue cells of non-neoplastic tissues. They produce synthesis of fibrillar structures and the basic substance, govern the extent and nature of the carcinoma stroma. The location and nature of tumor growth, blood supply and lymphoid infiltration affect the activity of fibroblasts and morphogenesis of the stroma. The marked correlation of stromal volumes in primary carcinomas and their metastases suggests that carcinoma cells make an important contribution to fibroblast stimulation.