Pancreatic involvement in cystic fibrosis

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Yesim Ozen Alahdab1, Deniz G Duman

  • 1Department of Gastroenterology, Marmara University School of Medicine, Istanbul, Turkey - yesimalahdab@yahoo.com.

Minerva Medica
|July 19, 2016
PubMed

Insights

Cystic fibrosis (CF) affects the pancreas, causing exocrine and endocrine dysfunction. This review details CF pancreatic disease types, clinical presentation, diagnosis, and genetics.

Area of Science:

  • Gastroenterology
  • Genetics
  • Pediatrics

Background:

  • Cystic fibrosis (CF) is a genetic disorder impacting multiple organs, notably the pancreas.
  • Improved patient care allows for observation across all age groups.
  • Pancreatic involvement is a significant aspect of CF pathology.

Purpose of the Study:

  • To review the pancreatic manifestations of cystic fibrosis.
  • To outline the disease types, clinical features, and diagnostic approaches.
  • To discuss the genetic underpinnings of CF-related pancreatic disease.

Main Methods:

  • Literature review of cystic fibrosis and pancreatic involvement.
  • Synthesis of information on clinical presentation and diagnosis.
  • Analysis of genetic factors contributing to pancreatic complications.

Main Results:

  • CF frequently impacts the exocrine pancreas, leading to dysfunction.
  • Endocrine pancreatic function can also be compromised.
  • Pancreatic parenchymal damage, including pancreatitis, may occur.

Conclusions:

  • Pancreatic involvement is a critical component of cystic fibrosis management.
  • Understanding the spectrum of pancreatic disease in CF is essential for patient care.
  • Genetic factors play a key role in the development of pancreatic complications in CF.

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