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Atherosclerosis I: Introduction

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...

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Updated: Mar 17, 2026

Quantification of Atherosclerosis in Mice

Quantification of Atherosclerosis in Mice

Published on: June 12, 2019

Global transcriptomic study of atherosclerosis development in rats.

Lei Chen¹, Hong Yao¹, Ji-Yuan Hui¹

¹Department of Neurosurgery, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, People's Republic of China.

|July 19, 2016

Summary

This summary is machine-generated.

This study reveals global transcriptomic changes in atherosclerosis, identifying key molecular pathways and long non-coding RNAs (lncRNAs) like GAS5, SNHG6, and Zfas1 involved in plaque development. These findings offer potential new therapeutic targets for this widespread arterial disease.

Keywords:

Atherosclerosis Transcriptomic lncRNA mRNA

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Isolation and Analysis of Aortic Arch and Root Lesions in an Atherosclerotic Mouse Model

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Area of Science:

Cardiovascular Biology
Molecular Pathology
Genomics

Background:

Atherosclerosis is a major global cause of mortality, characterized by arterial wall disease.
Current understanding of atherosclerosis pathophysiology lacks comprehensive data on global arterial changes during disease progression.
Evidence regarding the molecular mechanisms driving atherosclerotic plaque formation remains incomplete.

Purpose of the Study:

To investigate global transcriptomic alterations in carotid arteries during atherosclerosis development in a rat model.
To identify key molecular pathways and regulatory elements, including long non-coding RNAs (lncRNAs), implicated in atherosclerotic plaque formation.
To establish a global transcriptomic network for atherosclerosis to uncover potential clinical targets.

Main Methods:

Atherosclerosis was induced in a rat model.
GeneChip analysis was performed on carotid arteries with and without atherosclerotic plaques.
Transcriptomic data was analyzed to identify differentially expressed genes and lncRNAs.

Main Results:

Molecular pathways associated with immune response, angiogenesis, cell proliferation, apoptosis, and hypoxia were significantly altered in atherosclerotic arteries.
Three specific lncRNAs—GAS5, SNHG6, and Zfas1—were found to be significantly upregulated in atherosclerotic plaques compared to normal arterial tissue.
A complex interplay between messenger RNAs (mRNAs) and lncRNAs was identified in the context of atherosclerosis.

Conclusions:

Atherosclerosis involves diverse and complex molecular pathways contributing to plaque formation.
GAS5, SNHG6, and Zfas1 represent potential biomarkers or therapeutic targets for atherosclerosis.
The study provides a comprehensive transcriptomic network of atherosclerosis, paving the way for future clinical applications.