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Plasmablastic lymphoma exclusively involving bones mimicking osteosarcoma in an immunocompetent patient: A case
Azmal Kabir Sarker1, Hyung-Jun Im, Jin Chul Paeng
1Department of Nuclear Medicine Fellowship of Koh Chang Soon Program, Seoul National University College of Medicine, Seoul, Korea National Institute of Nuclear Medicine and Allied Sciences, BAEC, BSMMU campus, Dhaka, Bangladesh Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, and College of Medicine or College of Pharmacy, Seoul National University Cancer Research Institute, College of Medicine, Seoul National University, Seoul, Korea.
Background:
It has been known that plasmablastic lymphoma (PBL) is a neoplasm of immunocompromised patients occurring in soft tissue of oral cavity or in the vicinity whereas bone is an unlikely site to harbor PBL. However, its occurrence is increasingly being reported in immunocompetent individuals in either osseous or extra-oral sites. To our best knowledge, F-18 FDG PET/CT findings of PBL involving bones in an immunocompetent patient have not been reported, yet .
Case Summary:
We report a case of PBL involving multiple bones in an immunocompetent patient. Features of different imaging modalities including F-18 Fluoro-deoxy glucose (FDG) positron emission tomography/computed tomography (PET/CT) were correlated well as findings of osteosarcoma in mandible with metastatic lesions. However, the histopathology and immunohistochemistry (IHC) of bone tissues from 2 separate biopsy sites revealed features of PBL.
Conclusion:
awareness to F-18 FDG PET/CT findings of PBL involving bones in an immunocompetent patient may prevent misdiagnosis.
