Engaging Transgender People in NIH-Funded HIV/AIDS Clinical Trials Research

Area of Science:

• Public Health
• Health Services Research
• Clinical Trials

Background:

• The National Institutes of Health (NIH) identified a need to improve understanding of lesbian, gay, bisexual, and transgender (LGBT) health in the U.S.
• A key Institute of Medicine report highlighted the necessity for more LGBT health knowledge, better research methodologies, and enhanced physician/researcher training.
• Several NIH-funded HIV/AIDS clinical trials networks have prioritized engaging transgender individuals in research.

Purpose of the Study:

• To describe the approaches used by NIH-funded HIV/AIDS clinical trials networks to engage transgender (TG) individuals in research.
• To identify strategies for improving the inclusion and participation of TG individuals in health research.
• To address the specific research needs of the TG community, particularly concerning HIV/AIDS.

Main Methods:

• Networks established partnerships and advisory groups to gain input from the TG community on research plans.
• Data collection forms were revised to include the 2-step method for collecting sex at birth and gender identity.
• Research protocols and policies were updated to ensure appropriateness for TG participant inclusion.
• Training programs were developed to enhance cultural sensitivity among research staff.

Main Results:

• Multiple NIH-funded HIV/AIDS networks have implemented strategies to engage TG individuals in clinical research.
• Partnership building and community input have been crucial for developing trust and relevant research plans.
• Revisions to data collection and protocols facilitate more accurate and inclusive research.
• Enhanced cultural sensitivity training and resources support research staff.

Conclusions:

• NIH-funded HIV/AIDS networks are actively working to improve the engagement of transgender individuals in research.
• Collaborative approaches and methodological adaptations are essential for inclusive and effective research with TG populations.
• Continued focus on TG-specific research needs is vital for advancing the health of transgender individuals, especially in the context of HIV/AIDS.