Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pulmonary Tuberculosis IV01:26

Pulmonary Tuberculosis IV

617
Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
617

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Outcomes for clinical trials involving adults with chronic kidney disease: a multinational Delphi survey involving patients, caregivers and health professionals.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association·2024
Same author

Overcoming barriers to deliver high quality kidney care.

Nature reviews. Nephrology·2024
Same author

Identifying Barriers and Facilitators for Increasing Uptake of Sodium-Glucose Cotransporter-2 (SGLT2) Inhibitors in British Columbia, Canada, using the Consolidated Framework for Implementation Research.

Canadian journal of kidney health and disease·2024
Same author

Kidney biopsies among persons living in hotspots of CKDu: a position statement from the International Society of Nephrology's Consortium of Collaborators on CKDu.

Kidney international·2023
Same author

Patient and Clinician Experiences With the Combination of Virtual and In-Person Chronic Kidney Disease Care Since the COVID-19 Pandemic.

Canadian journal of kidney health and disease·2023
Same author

Predicting Outcomes in Nephrology: Lots of Tools, Limited Uptake: How Do We Move Forward?

Journal of the American Society of Nephrology : JASN·2023

Related Experiment Video

Updated: Mar 17, 2026

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
10:27

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Published on: December 15, 2011

25.1K

Recognizing IgG4-related tubulointerstitial nephritis.

Shawna Mann1, Michael A Seidman2, Sean J Barbour3

  • 1Department of Medicine, University of British Columbia, 2775 Laurel Street, 10th Floor, Vancouver,, BC V5Z 1M9 Canada.

Canadian Journal of Kidney Health and Disease
|July 19, 2016
PubMed
Summary

Immunoglobulin G4-related tubulointerstitial nephritis (IgG4-TIN) is an emerging kidney disease. Early suspicion, diagnosis, and treatment with steroids or rituximab are key, but relapses are common, necessitating long-term monitoring.

Keywords:
Autoimmune tubulointerstitial nephritisEpidemiologyIgG4-related diseaseIgG4-related kidney diseaseIgG4-related tubulointerstitial nephritisTubulointerstitial nephritis

More Related Videos

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
09:43

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Published on: June 8, 2022

3.6K
Detection of MicroRNA Expression in the Kidneys of Immunoglobulin A Nephropathic Mice
05:39

Detection of MicroRNA Expression in the Kidneys of Immunoglobulin A Nephropathic Mice

Published on: July 8, 2020

2.2K

Related Experiment Videos

Last Updated: Mar 17, 2026

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
10:27

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Published on: December 15, 2011

25.1K
Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
09:43

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Published on: June 8, 2022

3.6K
Detection of MicroRNA Expression in the Kidneys of Immunoglobulin A Nephropathic Mice
05:39

Detection of MicroRNA Expression in the Kidneys of Immunoglobulin A Nephropathic Mice

Published on: July 8, 2020

2.2K

Area of Science:

  • Nephrology
  • Immunology
  • Pathology

Background:

  • Immunoglobulin G4-related disease (IgG4-RD) is a systemic fibroinflammatory condition affecting multiple organs, with IgG4-related kidney disease (IgG4-RKD) being a significant manifestation.
  • IgG4-related tubulointerstitial nephritis (IgG4-TIN) represents the most prevalent form of IgG4-RKD and is increasingly recognized as a distinct clinicopathological entity.

Purpose of the Study:

  • To outline the clinical suspicion criteria for IgG4-TIN.
  • To provide a comprehensive summary of the diagnostic approaches, therapeutic strategies, and natural history of IgG4-TIN.

Main Methods:

  • A literature search was conducted using Ovid MEDLINE, Google Scholar, and PubMed for English-language articles published up to January 2016.
  • Relevant references were selected at the authors' discretion for inclusion in this review.

Main Results:

  • IgG4-TIN should be suspected in patients with abnormal urinalysis, impaired kidney function, renal imaging abnormalities, and elevated serum IgG, IgE, or hypocomplementemia.
  • Diagnosis relies on characteristic histology (plasma cell-rich tubulointerstitial nephritis with abundant IgG4+ plasma cells) combined with imaging findings, elevated serum IgG4, or IgG4-RD in other organs. Other conditions mimicking IgG4-TIN must be excluded.
  • Treatment typically involves corticosteroids and B-cell depletion therapy (rituximab), though relapses are frequent, underscoring the need for vigilant long-term follow-up.

Conclusions:

  • Current understanding of IgG4-TIN is primarily based on retrospective observational data.
  • Nephrologists must be adept at recognizing and managing IgG4-TIN. Further prospective studies and multi-center clinical trials are essential to elucidate its epidemiology, optimal treatment, and long-term outcomes.