Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Long-term Depression01:05

Long-term Depression

33.6K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
33.6K
Depressive Disorders: Etiology01:27

Depressive Disorders: Etiology

834
Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
834
Depression: Overview01:18

Depression: Overview

1.2K
Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
1.2K
G-protein Coupled Receptors01:21

G-protein Coupled Receptors

133.8K
G-protein coupled receptors are ligand binding receptors that indirectly affect changes in the cell. The actual receptor is a single polypeptide that transverses the cell membrane seven times creating intracellular and extracellular loops. The extracellular loops create a ligand specific pocket which binds to neurotransmitters or hormones. The intracellular loops holds onto the G-protein.
133.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clinical validation of an AI-based blood testing device for diagnosis and prognosis of acute infection and sepsis.

Nature medicine·2025
Same author

IMX-SEV-3b mRNA classifier predicts ICU care and 30-day mortality in febrile neutropenic emergency department patients.

The American journal of emergency medicine·2025
Same author

Analytical evaluation of TriVerity, a rapid diagnostic and prognostic host gene expression test performed on the Myrna instrument using RT-LAMP.

Journal of clinical microbiology·2025
Same author

29-mRNA host response signatures for classification of bacterial infection, viral infection and disease progression in COVID-19 pneumonia: a post hoc analysis of the SAVE-MORE randomized clinical trial.

Intensive care medicine experimental·2025
Same author

Complementary role of transcriptomic endotyping and protein-based biomarkers for risk stratification in sepsis-associated acute kidney injury.

Critical care (London, England)·2025
Same author

Early sepsis recognition: a pilot study using a rapid high-multiplex host-response mRNA diagnostic test.

Intensive care medicine experimental·2025

Related Experiment Video

Updated: Mar 17, 2026

3-D Imaging and Analysis of Neurons Infected In Vivo with Toxoplasma gondii
06:33

3-D Imaging and Analysis of Neurons Infected In Vivo with Toxoplasma gondii

Published on: December 9, 2014

12.0K

Toxoplasma Gondii Infection and Depression: A Case-Control Seroprevalence Study.

Cosme Alvarado-Esquivel1, Luis Francisco Sánchez-Anguiano2, Jesús Hernández-Tinoco2

  • 1Faculty of Medicine and Nutrition, Juárez University of Durango State, Avenida Universidad S/N , 34000 Durango, Dgo, Mexico.

European Journal of Microbiology & Immunology
|July 19, 2016
PubMed
Summary

Toxoplasma gondii infection may be linked to depression. This study found higher rates of T. gondii antibodies in depressed psychiatric patients compared to controls, especially in younger individuals.

Keywords:
Toxoplasmagondiicase–control studydepressionpsychiatric patientsseroprevalence

More Related Videos

Toxoplasma gondii Cyst Wall Formation in Activated Bone Marrow-derived Macrophages and Bradyzoite Conditions
09:56

Toxoplasma gondii Cyst Wall Formation in Activated Bone Marrow-derived Macrophages and Bradyzoite Conditions

Published on: August 12, 2010

16.8K
Obtaining Highly Purified Toxoplasma gondii Oocysts by a Discontinuous Cesium Chloride Gradient
11:17

Obtaining Highly Purified Toxoplasma gondii Oocysts by a Discontinuous Cesium Chloride Gradient

Published on: November 3, 2009

14.2K

Related Experiment Videos

Last Updated: Mar 17, 2026

3-D Imaging and Analysis of Neurons Infected In Vivo with Toxoplasma gondii
06:33

3-D Imaging and Analysis of Neurons Infected In Vivo with Toxoplasma gondii

Published on: December 9, 2014

12.0K
Toxoplasma gondii Cyst Wall Formation in Activated Bone Marrow-derived Macrophages and Bradyzoite Conditions
09:56

Toxoplasma gondii Cyst Wall Formation in Activated Bone Marrow-derived Macrophages and Bradyzoite Conditions

Published on: August 12, 2010

16.8K
Obtaining Highly Purified Toxoplasma gondii Oocysts by a Discontinuous Cesium Chloride Gradient
11:17

Obtaining Highly Purified Toxoplasma gondii Oocysts by a Discontinuous Cesium Chloride Gradient

Published on: November 3, 2009

14.2K

Area of Science:

  • Infectious Diseases
  • Psychiatry
  • Epidemiology

Background:

  • Toxoplasma gondii (T. gondii) is a parasite with a known ability to affect host behavior.
  • The potential link between T. gondii infection and psychiatric disorders, including depression, warrants further investigation.

Purpose of the Study:

  • To investigate the association between T. gondii infection and depression in a psychiatric patient population.
  • To compare the seroprevalence of T. gondii in depressed patients versus non-depressed controls.

Main Methods:

  • An age- and gender-matched case-control study was conducted.
  • 89 depressed psychiatric patients and 356 non-depressed controls from Durango City, Mexico, were included.
  • Enzyme-linked immunoassays were used to detect anti-T. gondii IgG and IgM antibodies.

Main Results:

  • A higher prevalence of anti-T. gondii IgG antibodies was observed in depressed patients (12.4%) compared to controls (6.2%), indicating a significant association (OR = 2.14, P = 0.04).
  • Younger patients (≤30 years old) with depression showed a significantly higher seroprevalence of T. gondii infection compared to age-matched controls (P = 0.001).
  • No significant difference in anti-T. gondii IgM antibodies was found between cases and controls.

Conclusions:

  • The study suggests a potential association between T. gondii infection and depression.
  • Further research is recommended to confirm these findings and explore the epidemiology of T. gondii in young depressed patients.