Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Polygenic Traits01:18

Polygenic Traits

70.2K
When more than one gene is responsible for a given phenotype, the trait is considered polygenic. Human height is a polygenic trait. Studies have uncovered hundreds of loci that influence height, and there are believed to be many more. Due to the high number of genes involved, as well as environmental and nutritional factors, height varies significantly within a given population. The distribution of height forms a bell-shaped curve, with relatively few individuals in the population at the...
70.2K
Polygenic Traits01:18

Polygenic Traits

11.3K
11.3K
Genetic Screens02:46

Genetic Screens

5.8K
Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which...
5.8K
Human Genetics01:28

Human Genetics

1.8K
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
1.8K
Behavioral Genetics and Its Designs01:23

Behavioral Genetics and Its Designs

1.3K
Behavior genetics explores how genetic inheritance influences human behavior. It focuses on how genes, passed from parents to offspring, contribute to the development of behavioral traits and tendencies. This branch of genetics seeks to understand the complex interplay between inherited genetic factors and environmental influences in shaping our behaviors.
The primary methodologies used in behavior genetics include family studies, twin studies, and adoption studies, each providing unique...
1.3K
Biological Influences on Intelligence01:30

Biological Influences on Intelligence

642
Intelligence is often thought to be linked to brain size, but the relationship is more complex than that. While brain size does correlate modestly with some abilities, like verbal skills, the connection is weaker for others, such as spatial reasoning. Other factors, like brain structure, also play crucial roles. For instance, despite Einstein's smaller-than-average brain, his parietal cortex, which is involved in spatial reasoning, was 15% wider, suggesting that neural density might matter...
642

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A genome-wide association study for extremely high intelligence.

Molecular psychiatry·2018
Same author

Widespread covariation of early environmental exposures and trait-associated polygenic variation.

Proceedings of the National Academy of Sciences of the United States of America·2017
Same author

Predicting educational achievement from DNA.

Molecular psychiatry·2017
Same author

Multi-polygenic score approach to trait prediction.

Molecular psychiatry·2017
Same author

Phenome-wide analysis of genome-wide polygenic scores.

Molecular psychiatry·2015
Same author

Genetic link between family socioeconomic status and children's educational achievement estimated from genome-wide SNPs.

Molecular psychiatry·2015
Same journal

Genome-wide genetic overlap between fear-based disorders and generalised anxiety disorder.

Molecular psychiatry·2026
Same journal

Cannabis use and glutamate across the psychosis spectrum: in vivo evidence from 7T proton magnetic resonance spectroscopy.

Molecular psychiatry·2026
Same journal

Subtyping OCD based on individual symptom networks: subtype-specific neural dynamics and morphometric similarity linked to molecular profiles.

Molecular psychiatry·2026
Same journal

Atrophy in preclinical Alzheimer's disease maps to a network that predicts longitudinal decline.

Molecular psychiatry·2026
Same journal

Towards modelling mental disorders in zebrafish. Neurexins severely modulate anxiety, affiliative social behaviour and aggression.

Molecular psychiatry·2026
Same journal

Targeting cortico-striatal-amygdalar networks via theta-band frontoparietal synchronization in opioid use disorder: a randomized tACS-fMRI Trial.

Molecular psychiatry·2026
See all related articles

Related Experiment Video

Updated: Mar 17, 2026

Using Cholesky Decomposition to Explore Individual Differences in Longitudinal Relations between Reading Skills
06:52

Using Cholesky Decomposition to Explore Individual Differences in Longitudinal Relations between Reading Skills

Published on: September 17, 2019

6.8K

Predicting educational achievement from DNA.

S Selzam1, E Krapohl1, S von Stumm2

  • 1King's College London, MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, London, UK.

Molecular Psychiatry
|July 20, 2016
PubMed
Summary
This summary is machine-generated.

A new genome-wide polygenic score (GPS) for educational attainment significantly predicts educational achievement, explaining up to 9% of variance by age 16. This score also correlates with cognitive ability and socioeconomic status.

More Related Videos

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information
09:37

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information

Published on: August 15, 2019

10.6K
An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations
10:17

An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations

Published on: November 3, 2010

23.4K

Related Experiment Videos

Last Updated: Mar 17, 2026

Using Cholesky Decomposition to Explore Individual Differences in Longitudinal Relations between Reading Skills
06:52

Using Cholesky Decomposition to Explore Individual Differences in Longitudinal Relations between Reading Skills

Published on: September 17, 2019

6.8K
Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information
09:37

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information

Published on: August 15, 2019

10.6K
An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations
10:17

An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations

Published on: November 3, 2010

23.4K

Area of Science:

  • Behavioral genetics
  • Quantitative trait prediction
  • Social sciences

Background:

  • Genome-wide polygenic scores (GPS) are increasingly used to predict complex traits.
  • Previous educational attainment GPS explained 2-4% of variance in educational years.
  • The predictive power of updated GPS for educational achievement requires further investigation.

Purpose of the Study:

  • To evaluate the predictive accuracy of an updated educational attainment GPS.
  • To assess the association of this GPS with educational achievement across different ages.
  • To examine the relationship between the GPS, cognitive ability, and socioeconomic status.

Main Methods:

  • Utilized an independent sample of 5825 UK individuals.
  • Tested the association between the latest educational attainment GPS and educational achievement scores at ages 7, 12, and 16.
  • Assessed correlations with general cognitive ability and family socioeconomic status.

Main Results:

  • The educational attainment GPS explained up to 9% of the variance in educational achievement by age 16.
  • This represents the strongest GPS prediction for quantitative behavioral traits to date.
  • Individuals in the highest and lowest GPS septiles differed by a full school grade at age 16.
  • GPS was associated with general cognitive ability (approx. 3.5%) and family socioeconomic status (approx. 7%).

Conclusions:

  • Updated educational attainment GPS demonstrates substantial predictive power for educational achievement over time.
  • GPS shows significant associations with cognitive ability and socioeconomic status, highlighting genetic influences on behavioral traits.
  • These findings support the potential for widespread use of GPS in predicting genetic risk and resilience in behavioral sciences.