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Updated: Mar 17, 2026

A Rat Tibial Growth Plate Injury Model to Characterize Repair Mechanisms and Evaluate Growth Plate Regeneration Strategies
Published on: July 4, 2017
Abstract:
In brief: About 10% of skeletal trauma in childhood involves epiphyseal injury, which can result in major skeletal growth disturbances. Limb-length discrepancies and joint angle deformities can be prevented by understanding (1) the mechanism and patterns of longitudinal bone growth, (2) the significance of skeletal maturational variances at different ages, (3) the probable locations of epiphyseal injuries, (4) the physical and radiographic signs of epiphyseal injury, and (5) the procedures available for treating deformities that result from epiphyseal injuries. Salter-Harris type I and II injuries are usually successfully treated by closed manipulation and adequate immobilization. Type III, IV, and V injuries often require surgery to achieve satisfactory alignment.
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