Related Experiment Videos
Effect of V-9-M, a peptide fragment derived from procholecystokinin, on memory processes in the rat
1Shionogi Research Laboratories, Osaka, Japan.
Abstract:
It has been reported that a nonapeptide (Val-Pro-Val-Glu-Ala-Val-Asp-Pro-Met) called V-9-M is produced from procholecystokinin in the brain. Since this peptide is particularly abundant in the hippocampus, septum, and amygdala. V-9-M may be involved in memory processes. The present study was attempted to observe the effect of V-9-M on memory processes of rat performing a one-trial passive avoidance task and a platform jumping active avoidance task. The results indicate that injection of V-9-M into the lateral ventricle of the rat prevents experimental amnesia induced by electroconvulsive shock in passive avoidance testing, and that this effect is not significantly affected by cholecystokinin-8 antagonists. V-9-M also causes a long-lasting enhancement of memory in the active avoidance task. These results suggest that V-9-M may participate in the facilitation of memory.
Insights
The brain peptide V-9-M, derived from procholecystokinin, enhances memory in rats. This nonapeptide (Val-Pro-Val-Glu-Ala-Val-Asp-Pro-Met) shows promise for memory improvement and treating amnesia.
Area of Science:
- Neuroscience
- Molecular Biology
- Behavioral Science
Background:
- A nonapeptide, V-9-M (Val-Pro-Val-Glu-Ala-Val-Asp-Pro-Met), is produced from procholecystokinin in the brain.
- V-9-M is notably abundant in brain regions associated with memory, including the hippocampus, septum, and amygdala.
Purpose of the Study:
- To investigate the effects of V-9-M on memory processes in rats.
- To assess V-9-M's role in both passive and active avoidance learning tasks.
Main Methods:
- Rats were trained on a one-trial passive avoidance task and a platform jumping active avoidance task.
- V-9-M was administered intracerebroventricularly.
- Experimental amnesia was induced using electroconvulsive shock.
- The influence of cholecystokinin-8 antagonists was evaluated.
Main Results:
- Intracerebroventricular injection of V-9-M prevented electroconvulsive shock-induced amnesia in the passive avoidance task.
- This protective effect was not significantly altered by cholecystokinin-8 antagonists.
- V-9-M administration resulted in a sustained enhancement of memory performance in the active avoidance task.
Conclusions:
- V-9-M appears to play a role in memory facilitation.
- The peptide demonstrates potential therapeutic applications for memory disorders and amnesia.