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Admission Values of D-dimer and C-reactive Protein (CRP) Predict the Long-term Outcomes in Acute Aortic Dissection

Kentaro Mori1, Hidetaka Tamune, Hiroyuki Tanaka

  • 1Department of Emergency Rescue, Tokyo Metropolitan Tama Medical Center, Japan.

Internal Medicine (Tokyo, Japan)
|July 20, 2016
PubMed

Insights

Admission D-dimer and C-reactive protein (CRP) can predict long-term outcomes in acute aortic dissection (AAD). Elevated admission D-dimer is a valuable marker for predicting both short-term and long-term AAD prognosis.

Area of Science:

  • Cardiology
  • Vascular Surgery
  • Biomarkers

Background:

  • Acute aortic dissection (AAD) is a life-threatening condition.
  • Admission D-dimer and C-reactive protein (CRP) are known short-term outcome predictors in AAD.
  • Long-term outcome prediction using these biomarkers remains under-investigated.

Purpose of the Study:

  • To investigate the association between admission D-dimer and C-reactive protein (CRP) levels and long-term outcomes in patients with acute aortic dissection (AAD).
  • To determine optimal cut-off values for these biomarkers in predicting adverse events.

Main Methods:

  • Retrospective analysis of 173 AAD patients hospitalized between 2005 and 2013.
  • Receiver operating characteristic (ROC) analysis to determine optimal biomarker cut-off levels.
  • Multiple Cox regression analysis to assess hazard ratios for long-term adverse events.

Main Results:

  • Admission D-dimer levels showed a hazard ratio of 3.4 (95% CI 1.5-7.3, p=0.004) for adverse outcomes.
  • Admission CRP levels showed a hazard ratio of 2.7 (95% CI 1.2-5.5, p=0.014) for adverse outcomes.
  • Both biomarkers demonstrated predictive value for long-term prognosis.

Conclusions:

  • Admission D-dimer and CRP levels are significant predictors of long-term outcomes in AAD patients.
  • Admission D-dimer is a valuable marker for predicting both short-term and long-term prognosis in AAD.
  • These findings support the use of baseline D-dimer and CRP in risk stratification for AAD.

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