Hydrogen Sulfide Regulates Homeostasis of Mesenchymal Stem Cells and Regulatory T Cells

Hydrogen sulfide (H₂S) has long been known as a toxic gas. However, recently accumulated evidence suggests that H₂S contributes to a variety of physiologic and pathologic processes. Endogenous H₂S production is regulated by multiple enzymes that are differentially expressed in the cardiovascular, neuronal, immune, renal, respiratory, gastrointestinal, reproductive, liver, and endocrine systems. Alteration of H₂S metabolism may affect multiple signaling pathways and tissue homeostasis. The growing number of diverse targets for which H₂S serves as a gasotransmitter has been extensively reviewed elsewhere. In this review, the authors discuss current emerging evidence that H₂S regulates mesenchymal stem cell and T-cell functions.